Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex of normal rats and rats with mononeuropathy

被引：0

作者：

Meng-Lin Zhang

Hong-Bo Wang

Feng-Hua Fu

Long-Chuan Yu

机构：

[1] School of Pharmacy,

[2] Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University),undefined

[3] Ministry of Education,undefined

[4] Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,undefined

[5] Yantai University,undefined

[6] Neurobiology Laboratory,undefined

[7] College of Life Sciences,undefined

[8] Peking University,undefined

来源：

Scientific Reports | / 7卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The present study was performed to explore the role of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex (ACC) of normal rats and rats with mononeuropathy. Intra-ACC injection of galanin induced significant increases in hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulations in both normal rats and rats with mononeuropathy, the increased HWLs were attenuated significantly by intra-ACC injection of galanin receptor 2 antagonist M871, indicating an involvement of galanin receptor 2 in nociceptive modulation in ACC. Interestingly, the galanin-induced HWL was significant higher in rats with mononeuropathy than that in normal rats tested by Randall Selitto test. Furthermore, both the galanin mRNA expression and galanin content increased significantly in ACC in rats with mononeuropathy than that in normal rats. Moreover, both the mRNA levels of galanin receptor 2 and the content of galanin receptor 2 in ACC increased significantly in rats with mononeuropathy than that in normal rats. These results found that galanin induced antinociception in ACC in both normal rats and rats with mononeuropathy. And there may be plastic changes in the expression of galanin and galanin receptor 2 in rats with mononeuropathy, as well as in the galanin-induced antinociception.

引用

共 101 条

[1]

Tatemoto K(1983)Galanin—a novel biologically active peptide from porcine intestine FEBS Letters 164 124-128

[2]

Rokaeus A(1986)Distribution of galanin-like immunoreactivity in the rat central nervous system J. Comp. Neurol. 248 475-517

[3]

Jornvall H(2000)The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease Galanin receptor subtypes. Trends Pharmacol. Sci 21 109-117

[4]

Mcdonald TJ(2007)Galanin, galanin receptors and drug targets Pharmacol. Ther 115 177-207

[5]

Mutt V(2008)Galanin protects amyloid-β-induced neurotoxicity on hippocampal neurons in rats Cell. Mol. Life Sci 65 1796-1805

[6]

Melander T(2010)Galanin–25 years with a multitalented neuropeptide J. Alzheimer’s Dis 20 1143-1157

[7]

Hokfelt T(2008)Galanin function in the central nervous system Cell Mol. Life Sci 65 1793-1795

[8]

Rokaeus A(2006)Effects of exogenous galanin on neuropathicpain state and change of galanin and its receptors in DRG and SDH after sciatic nerve-pinch injury in rat Curr. Opin. Drug Disc 9 560-570

[9]

Branchek TA(2012)A role of supraspinal galanin in behavioural hyperalgesia in the rat PLoS One 7 e37621-176

[10]

Smith KE(2014)Galanin-mediated behavioural hyperalgesia from the dorsomedial nucleus of the hypothalamus involves two independent descending pronociceptive pathways PLoS One 9 e113077-335

← 1 2 3 4 5 6 7 8 9 10 →