Attenuated Toxoplasma gondii enhances the antitumor efficacy of anti-PD1 antibody by altering the tumor microenvironment in a pancreatic cancer mouse model

被引：0
作者：
Said Ahmed Bahwal
Jane J. Chen
Lilin E
Taofang Hao
Jiancong Chen
Vern B. Carruthers
Jiaming Lai
Xingwang Zhou
机构：
[1] Sun Yat-Sen University,Department of Biochemistry and Molecular Biology, Sun Yat
[2] Warren Alpert Medical School of Brown University,Sen University Zhongshan School of Medicine
[3] Sun Yat-Sen University,Department of Pancreato
[4] University of Michigan School of Medicine,Biliary Surgery, The First Affiliated Hospital
来源：
Journal of Cancer Research and Clinical Oncology | 2022年 / 148卷
关键词：
Dendritic cells; Immunotherapy; Programmed cell death 1 receptor; Vaccination;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：2743 / 2757
页数：14
相关论文
共 50 条
  • [41] CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial
    Montagne, Janelle M.
    Mitchell, Jacob T.
    Tandurella, Joseph A.
    Christenson, Eric S.
    Danilova, Ludmila, V
    Deshpande, Atul
    Loth, Melanie
    Sidiropoulos, Dimitrios N.
    Davis-Marcisak, Emily
    Bergman, Daniel R.
    Zhu, Qingfeng
    Wang, Hao
    Kagohara, Luciane T.
    Engle, Logan L.
    Green, Benjamin F.
    Favorov, Alexander, V
    Ho, Won Jin
    Lim, Su Jin
    Zhang, Rui
    Li, Pan
    Gai, Jessica
    Mo, Guanglan
    Mitchell, Sarah
    Wang, Rulin
    Vaghasia, Ajay
    Hou, Wenpin
    Xu, Yao
    Zimmerman, Jacquelyn W.
    Elisseeff, Jennifer H.
    Yegnasubramanian, Srinivasan
    Anders, Robert A.
    Jaffee, Elizabeth M.
    Zheng, Lei
    Fertig, Elana J.
    ISCIENCE, 2025, 28 (01)
  • [42] Cancer Stem Cell Vaccination With PD-L1 and CTLA-4 Blockades Enhances the Eradication of Melanoma Stem Cells in a Mouse Tumor Model
    Zheng, Fang
    Dang, Jianzhong
    Zhang, Hongyu
    Xu, Fangzhou
    Ba, Diandian
    Zhang, Bingyu
    Cheng, Fanjun
    Chang, Alfred E.
    Wicha, Max S.
    Li, Qiao
    JOURNAL OF IMMUNOTHERAPY, 2018, 41 (08) : 361 - 368
  • [43] Low-dose paclitaxel enhances the anti-tumor efficacy of GM-CSF surface-modified whole-tumor-cell vaccine in mouse model of prostate cancer
    He, Qiushan
    Li, Jinlong
    Yin, Weihua
    Song, Zhichun
    Zhang, Zhen
    Yi, Tienan
    Tang, Jia
    Wu, Demin
    Lu, Yue
    Wang, Zhen
    Liu, Dan
    Zhang, Xiaoren
    Hu, Zhiming
    Gao, Jimin
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2011, 60 (05) : 715 - 730
  • [44] CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer
    Yang, Moran
    Lu, Jiaqi
    Zhang, Guodong
    Wang, Yiying
    He, Mengdi
    Xu, Qing
    Xu, Congjian
    Liu, Haiou
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 (01)
  • [45] Combination therapy with PD-1 inhibition plus rapamycin and metformin enhances anti-tumor efficacy in triple negative breast cancer
    Tan, Xiaoying
    Li, Yan
    Hou, Zhihui
    Zhang, Mingwei
    Li, Li
    Wei, Junmin
    EXPERIMENTAL CELL RESEARCH, 2023, 429 (01)
  • [46] CNOT4 enhances the efficacy of anti-PD-1 immunotherapy in a model of non-small cell lung cancer
    Zhang, Biao
    Han, Song
    Ma, Haitao
    Chen, Shaomu
    FEBS OPEN BIO, 2020, 10 (12): : 2631 - 2639
  • [47] Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer
    Ye, Jian
    Mills, Bradley N.
    Qin, Shuyang S.
    Garrett-Larsen, Jesse
    Murphy, Joseph D.
    Uccello, Taylor P.
    Han, Booyeon J.
    Vrooman, Tara G.
    Johnston, Carl J.
    Lord, Edith M.
    Belt, Brian A.
    Linehan, David C.
    Gerber, Scott A.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (07)
  • [48] Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model
    Luheshi, Nadia M.
    Coates-Ulrichsen, Jane
    Harper, James
    Mullins, Stefanie
    Sulikowski, Michal G.
    Martin, Philip
    Brown, Lee
    Lewis, Arthur
    Davies, Gareth
    Morrow, Michelle
    Wilkinson, Robert W.
    ONCOTARGET, 2016, 7 (14) : 18508 - 18520
  • [49] Treatment with a VEGFR-2 antibody results in intra-tumor immune modulation and enhances anti-tumor efficacy of PD-L1 blockade in syngeneic murine tumor models
    Li, Yanxia
    Amaladas, Nelusha
    O'Mahony, Marguerita
    Manro, Jason R.
    Inigo, Ivan
    Li, Qi
    Rasmussen, Erik R.
    Brahmachary, Manisha
    Doman, Thompson N.
    Hall, Gerald
    Kalos, Michael
    Novosiadly, Ruslan
    Puig, Oscar
    Pytowski, Bronislaw
    Schaer, David A.
    PLOS ONE, 2022, 17 (07):
  • [50] MK-3475 (ANTI-PD-1 MONOCLONAL ANTIBODY) FOR NON-SMALL CELL LUNG CANCER (NSCLC): ANTITUMOR ACTIVITY AND ASSOCIATION WITH TUMOR PD-L1 EXPRESSION
    Gandhi, Leena
    Lubiniecki, Gregory
    Balmanoukian, Ani
    Hui, Rina
    Hamid, Omid
    Rizvi, Naiyer A.
    Leighl, Natasha
    Gubens, Matthew
    Goldman, Jonathan W.
    Emancipator, Kenneth
    Dolled-Filhart, Marisa
    Lunceford, Jared K.
    Niewood, Michelle
    Gergich, Kevin
    Garon, Edward B.
    JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (09) : S154 - S154
12345