Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

被引：0

作者：

Jan H Kessler

Selina Khan

Ulrike Seifert

Sylvie Le Gall

K Martin Chow

Annette Paschen

Sandra A Bres-Vloemans

Arnoud de Ru

Nadine van Montfoort

Kees L M C Franken

Willemien E Benckhuijsen

Jill M Brooks

Thorbald van Hall

Kallol Ray

Arend Mulder

Ilias I N Doxiadis

Paul F van Swieten

Hermen S Overkleeft

Annik Prat

Birgitta Tomkinson

Jacques Neefjes

Peter M Kloetzel

David W Rodgers

Louis B Hersh

Jan W Drijfhout

Peter A van Veelen

Ferry Ossendorp

Cornelis J M Melief

机构：

[1] Leiden University Medical Center,Department of Immunohematology and Blood Transfusion

[2] Institut für Biochemie-Charité,Department of Molecular and Cellular Biochemistry

[3] Medical Faculty of the Humboldt University Berlin,Department of Dermatology

[4] Berlin,Department of Clinical Oncology

[5] Germany.,Department of Medical Biochemistry and Microbiology

[6] Ragon Institute of MGH,Division of Cell Biology

[7] MIT and Harvard,undefined

[8] Boston,undefined

[9] Massachusetts,undefined

[10] USA.,undefined

[11] and Center for Structural Biology,undefined

[12] University of Kentucky,undefined

[13] Lexington,undefined

[14] Kentucky,undefined

[15] USA.,undefined

[16] University Clinics Essen,undefined

[17] Essen,undefined

[18] Germany.,undefined

[19] Cancer Research UK Institute for Cancer Studies,undefined

[20] University of Birmingham,undefined

[21] Leiden University Medical Center,undefined

[22] Leiden,undefined

[23] The Netherlands.,undefined

[24] Leiden Institute of Chemistry,undefined

[25] Leiden University,undefined

[26] Leiden,undefined

[27] The Netherlands.,undefined

[28] Laboratory of Biochemical Neuroendocrinology,undefined

[29] Clinical Research Institute of Montreal,undefined

[30] Uppsala University,undefined

[31] Uppsala,undefined

[32] Sweden.,undefined

[33] The Netherlands Cancer Institute,undefined

来源：

Nature Immunology | 2011年 / 12卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Peptides presented to cytotoxic T lymphocytes are typically generated by proteasome action. Kessler and colleagues show that the cytosolic endopeptidases nardilysin and thimet oligopeptidase generate the C termini of tumor-relevant epitopes.

引用

页码：45 / 53

页数：8

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