CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala

被引：0
|
作者：
Yu Zhou
Jaejoon Won
Mikael Guzman Karlsson
Miou Zhou
Thomas Rogerson
Jayaprakash Balaji
Rachael Neve
Panayiota Poirazi
Alcino J Silva
机构：
[1] University of California Los Angeles,Department of Neurobiology
[2] Semel Institute,Department of Psychology
[3] University of California Los Angeles,undefined
[4] University of California Los Angeles,undefined
[5] Brain Research Institute,undefined
[6] University of California Los Angeles,undefined
[7] Picower Institute,undefined
[8] Massachusetts Institute of Technology,undefined
[9] Computational Biology Laboratory,undefined
[10] Institute of Molecular Biology and Biotechnology (IMBB),undefined
[11] Foundation of Research and Technology Hellas,undefined
[12] Vassilika Vouton,undefined
[13] Present address: Department of Physiology,undefined
[14] Medical College of Qingdao University,undefined
[15] Qingdao,undefined
[16] China.,undefined
来源：
Nature Neuroscience | 2009年 / 12卷
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学科分类号：
摘要：
Silva et al. show that CREB modulates allocation of fear memory to specific cells in the lateral amygdala. Reversibly inactivating a subset of CREB-expressing neurons disrupted memory for tone conditioning. Neurons with higher CREB levels were more excitable than their neighbors and showed larger synaptic efficacy changes following tone conditioning.
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页码：1438 / 1443
页数：5
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