CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala

被引：0

作者：

Yu Zhou

Jaejoon Won

Mikael Guzman Karlsson

Miou Zhou

Thomas Rogerson

Jayaprakash Balaji

Rachael Neve

Panayiota Poirazi

Alcino J Silva

机构：

[1] University of California Los Angeles,Department of Neurobiology

[2] Semel Institute,Department of Psychology

[3] University of California Los Angeles,undefined

[4] University of California Los Angeles,undefined

[5] Brain Research Institute,undefined

[6] University of California Los Angeles,undefined

[7] Picower Institute,undefined

[8] Massachusetts Institute of Technology,undefined

[9] Computational Biology Laboratory,undefined

[10] Institute of Molecular Biology and Biotechnology (IMBB),undefined

[11] Foundation of Research and Technology Hellas,undefined

[12] Vassilika Vouton,undefined

[13] Present address: Department of Physiology,undefined

[14] Medical College of Qingdao University,undefined

[15] Qingdao,undefined

[16] China.,undefined

来源：

Nature Neuroscience | 2009年 / 12卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Silva et al. show that CREB modulates allocation of fear memory to specific cells in the lateral amygdala. Reversibly inactivating a subset of CREB-expressing neurons disrupted memory for tone conditioning. Neurons with higher CREB levels were more excitable than their neighbors and showed larger synaptic efficacy changes following tone conditioning.

引用

页码：1438 / 1443

页数：5

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