Caspase-1: is IL-1 just the tip of the ICEberg?

被引:0
|
作者
A Denes
G Lopez-Castejon
D Brough
机构
[1] Faculty of Life Sciences,
[2] University of Manchester,undefined
[3] AV Hill Building,undefined
[4] Oxford Road,undefined
[5] Manchester M13 9PT,undefined
[6] UK,undefined
来源
Cell Death & Disease | 2012年 / 3卷
关键词
caspase-1; inflammation; inflammasome;
D O I
暂无
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学科分类号
摘要
Caspase-1, formerly known as interleukin (IL)-1-converting enzyme is best established as the protease responsible for the processing of the key pro-inflammatory cytokine IL-1β from an inactive precursor to an active, secreted molecule. Thus, caspase-1 is regarded as a key mediator of inflammatory processes, and has become synonymous with inflammation. In addition to the processing of IL-1β, caspase-1 also executes a rapid programme of cell death, termed pyroptosis, in macrophages in response to intracellular bacteria. Pyroptosis is also regarded as a host response to remove the niche of the bacteria and to hasten their demise. These processes are generally accepted as the main roles of caspase-1. However, there is also a wealth of literature supporting a direct role for caspase-1 in non-infectious cell death processes. This is true in mammals, but also in non-mammalian vertebrates where caspase-1-dependent processing of IL-1β is absent because of the lack of appropriate caspase-1 cleavage sites. This literature is most prevalent in the brain where caspase-1 may directly regulate neuronal cell death in response to diverse insults. We attempt here to summarise the evidence for caspase-1 as a cell death enzyme and propose that, in addition to the processing of IL-1β, caspase-1 has an important and a conserved role as a cell death protease.
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页码:e338 / e338
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