Apolipoprotein E4 polymorphism as risk factor for coronary heart disease among Indian subjects

被引：4

作者：

Ashavaid T.F. ^{[1
]}

Todur S.P. ^{[1
]}

Nair K.G. ^{[1
]}

机构：

[1] Research Laboratories, P.D. Hinduja National Hospital, Medical Research Centre, Mahim, Mumbai-400 016, Veer Savarkar Marg

来源：

Indian Journal of Clinical Biochemistry | 2002年 / 17卷 / 1期

关键词：

Alleles; Apolipoprotein E genotypes;

D O I：

10.1007/BF02867947

中图分类号：

学科分类号：

摘要：

Apolipoprotein E genotypes and lipid and lipoprotein levels were determined in hypercholesterolemia and angiographically vertified CHD subjects and compared against 90 normolipidemic controls. The ε4 allele was significantly prevalent in the hypercholesterolemic and CHD subjects. Significant increase in total cholesterol levels in apo ε4 containing subjects were observed in the hypercholesterolemic and CHD group.The study suggests that the ε4 allele by influencing the lipid levels could act as a risk factor for CHD.

引用

页码：83 / 93

页数：10

共 29 条

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