Synchronous development of intrahepatic cholangiocarcinoma and hepatocellular carcinoma in different sites of the liver with chronic B-viral hepatitis: Two case reports

被引：10

作者：

Jung K.S. ^{[1
]}

Chun K.H. ^{[1
]}

Choi G.H. ^{[2
,4
,5
]}

Jeon H.M. ^{[3
]}

Shin H.S. ^{[1
]}

Park Y.N. ^{[3
,4
,5
]}

Park J.Y. ^{[1
,4
,5
]}

机构：

[1] Department of Internal Medicine, Yonsei University, College of Medicine, Seodaemun-gu, Seoul 120-752

[2] Department of Surgery, Yonsei University, College of Medicine, Seodaemun-gu, Seoul 120-752

[3] Department of Pathology, Yonsei University, College of Medicine, Seodaemun-gu, Seoul 120-752

[4] Institute of Gastroenterology, Yonsei University, College of Medicine, Seodaemun-gu, Seoul 120-752

[5] Liver Cancer Special Clinic, Severance Hospital, Seodaemun-gu, Seoul 120-752

来源：

BMC Research Notes | / 6卷 / 1期

关键词：

Chronic liver disease; Double primary liver cancer; Hepatitis B virus; Hepatocellular carcinoma; Intrahepatic cholangiocarcinoma;

D O I：

10.1186/1756-0500-6-520

中图分类号：

学科分类号：

摘要：

Background: Synchronous development of primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma has been reported rarely. In literature review, there have been only 35 reported cases of synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma, and most of these tumors developed in patients with hepatitis C-related liver cirrhosis. Here, we present synchronous development of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in two patients with chronic B-viral hepatitis. Case presentation. Two patients with chronic hepatitis B were referred to our hospital due to a hepatic mass. Patient 1 had a 6.4 cm multinodular hepatic mass in the left lobe and a small nodule in the right lobe. Patient 2 had a 4.3 cm hypervascular mass in the right lobe and a 1.1 cm nodule in the left lobe. The pre-operative diagnosis of both cases was hepatocellular carcinoma with metastatic nodule, however, surgical resection pathology revealed that hepatocellular carcinoma and intrahepatic cholangiocarcinoma existed independently in the other side of the liver in both cases. Additionally, the background liver histology of both cases was hepatitis B-related chronic hepatitis without cirrhotic change. Conclusion: Our cases suggest that hepatitis B virus infection can also predispose to development of double liver cancers. © 2013 Jung et al.; licensee BioMed Central Ltd.

引用

共 25 条

[1]

Fuji N., Taniguchi H., Amaike H., Oka K., Tsuchihashi Y., Urasaki K., Naito K., Synchronously resected double primary hepatic cancer, hepatocellular carcinoma and cholangiocarcinoma [4], Journal of Gastroenterology and Hepatology, 20, 6, pp. 967-969, (2005)

[2]

Matsuda M., Hara M., Suzuki T., Kono H., Fujii H., Synchronously resected double primary hepatic cancers - Hepatocellular carcinoma and cholangiolocellular carcinoma, Journal of Hepato-Biliary-Pancreatic Surgery, 13, 6, pp. 571-576, (2006)

[3]

Inaba K., Suzuki S., Sakaguchi T., Kobayasi Y., Takehara Y., Miura K., Baba S., Nakamura S., Konno H., Double primary liver cancer (intrahepatic cholangiocarcinoma and hepatocellular carcinoma) in a patient with hepatitis C virus-related cirrhosis, Journal of Hepato-Biliary-Pancreatic Surgery, 14, 2, pp. 204-209, (2007)

[4]

Watanabe T., Sakata J., Ishikawa T., Shirai Y., Suda T., Hirono H., Hasegawa K., Soga K., Shibasaki K., Saito Y., Umezu H., Synchronous development of HCC and CCC in the same subsegment of the liver in a patient with type C liver cirrhosis, World J Hepatol, 1, pp. 103-109, (2009)

[5]

Kwon Y., Lee S.K., Kim J.S., Ro J.Y., Yu E., Synchronous hepatocellular carcinoma and cholangiocarcinoma arising in two different dysplastic nodules, Mod Pathol, 15, pp. 1096-1101, (2002)

[6]

Kim Y.W., Park Y.K., Park J.H., Lee J., Lee S.M., Hong S.W., Yang M.H., A case with intrahepatic double cancer: Hepatocellular carcinoma and cholangiocarcinoma associated with multiple von Meyenburg complexes, Yonsei Med J, 40, pp. 506-509, (1999)

[7]

Yoshida H., Shiratori Y., Moriyama M., Arakawa Y., Ide T., Sata M., Inoue O., Yano M., Tanaka M., Fujiyama S., Nishiguchi S., Kuroki T., Imazeki F., Yokosuka O., Kinoyama S., Yamada G., Omata M., Interferon therapy reduces the risk for hepatocellular carcinoma: National surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan, Annals of Internal Medicine, 131, 3, pp. 174-181, (1999)

[8]

Kobayashi M., Ikeda K., Saitoh S., Suzuki F., Tsubota A., Suzuki Y., Arase Y., Murashima N., Chayama K., Kumada H., Incidence of primary cholangiocellular carcinoma of the liver in japanese patients with Hepatitis C virus-related cirrhosis, Cancer, 88, 11, pp. 2471-2477, (2000)

[9]

Llovet J.M., Burroughs A., Bruix J., Hepatocellular carcinoma, Lancet, 362, 9399, pp. 1907-1917, (2003)

[10]

Lee T.Y., Lee S.S., Jung S.W., Jeon S.H., Yun S.C., Oh H.C., Kwon S., Lee S.K., Seo D.W., Kim M.H., Suh D.J., Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: A case-control study, Am J Gastroenterol, 103, pp. 1716-1720, (2008)

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