A high-throughput in vivo micronucleus assay for genome instability screening in mice

被引：0
|
作者：
Gabriel Balmus
Natasha A Karp
Bee Ling Ng
Stephen P Jackson
David J Adams
Rebecca E McIntyre
机构：
[1] The Wellcome Trust/Cancer Research UK Gurdon Institute,
[2] University of Cambridge,undefined
[3] Maintenance of Genome Stability,undefined
[4] The Wellcome Trust Sanger Institute,undefined
[5] Genome Campus,undefined
[6] The Sanger Mouse Genetics Project,undefined
[7] The Wellcome Trust Sanger Institute,undefined
[8] Genome Campus,undefined
[9] Cytometry Core Facility,undefined
[10] The Wellcome Trust Sanger Institute,undefined
[11] Genome Campus,undefined
[12] Experimental Cancer Genetics,undefined
[13] The Wellcome Trust Sanger Institute,undefined
[14] Genome Campus,undefined
来源：
Nature Protocols | 2015年 / 10卷
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D O I：
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中图分类号：
学科分类号：
摘要：
This protocol describes a sensitive, robust, high-throughput method for quantifying the formation of micronuclei in mouse erythrocytes. It detects low levels of genome instability and can be used to identify novel genome maintenance genes and models.
引用
收藏
页码：205 / 215
页数：10
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