Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving

被引：0

作者：

Dean F Wong

Hiroto Kuwabara

David J Schretlen

Katherine R Bonson

Yun Zhou

Ayon Nandi

James R Brašić

Alane S Kimes

Marika A Maris

Anil Kumar

Carlo Contoreggi

Jonathan Links

Monique Ernst

Olivier Rousset

Stephen Zukin

Anthony A Grace

Charles Rohde

Donald R Jasinski

Albert Gjedde

Edythe D London

机构：

[1] Johns Hopkins University School of Medicine,The Russell H. Morgan Department of Radiology and Radiological Science

[2] Johns Hopkins University School of Medicine,Department of Psychiatry and Behavioral Sciences

[3] Neuroimaging Research Branch,Departments of Neuroscience

[4] Intramural Research Program,Department of Biostatistics

[5] National Institute on Drug Abuse,Department of Medicine

[6] Environmental Health Sciences,Department of Psychiatry and Behavioral Sciences

[7] Bloomberg School of Public Health,Department of Molecular and Medical Pharmacology

[8] Johns Hopkins University,Section for Developmental and Affective Neuroscience

[9] Psychiatry and Psychology,undefined

[10] University of Pittsburgh,undefined

[11] Bloomberg School of Public Health,undefined

[12] Johns Hopkins University,undefined

[13] Center for Chemical Dependency,undefined

[14] Johns Hopkins Medical Institutions,undefined

[15] PET Center and Center of Functionally Integrative Neuroscience,undefined

[16] Aarhus City Hospital,undefined

[17] Aarhus University Hospitals,undefined

[18] Aarhus University,undefined

[19] David Geffen School of Medicine at UCLA,undefined

[20] David Geffen School of Medicine at UCLA,undefined

[21] The Brain Research Institute,undefined

[22] David Geffen School of Medicine at UCLA,undefined

[23] Controlled Substance Staff,undefined

[24] Food and Drug Administration,undefined

[25] Intramural Research Program,undefined

[26] National Institute of Mental Health,undefined

[27] Discovery Medicine,undefined

[28] AstraZeneca LP,undefined

来源：

Neuropsychopharmacology | 2006年 / 31卷

关键词：

PET neuroimaging; cocaine; dopamine release; cue-elicited craving; receptor occupancy; dopamine receptors;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [11C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.

引用

页码：2716 / 2727

页数：11

共 48 条

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