Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving

被引：0

作者：

Dean F Wong

Hiroto Kuwabara

David J Schretlen

Katherine R Bonson

Yun Zhou

Ayon Nandi

James R Brašić

Alane S Kimes

Marika A Maris

Anil Kumar

Carlo Contoreggi

Jonathan Links

Monique Ernst

Olivier Rousset

Stephen Zukin

Anthony A Grace

Charles Rohde

Donald R Jasinski

Albert Gjedde

Edythe D London

机构：

[1] Johns Hopkins University School of Medicine,The Russell H. Morgan Department of Radiology and Radiological Science

[2] Johns Hopkins University School of Medicine,Department of Psychiatry and Behavioral Sciences

[3] Neuroimaging Research Branch,Departments of Neuroscience

[4] Intramural Research Program,Department of Biostatistics

[5] National Institute on Drug Abuse,Department of Medicine

[6] Environmental Health Sciences,Department of Psychiatry and Behavioral Sciences

[7] Bloomberg School of Public Health,Department of Molecular and Medical Pharmacology

[8] Johns Hopkins University,Section for Developmental and Affective Neuroscience

[9] Psychiatry and Psychology,undefined

[10] University of Pittsburgh,undefined

[11] Bloomberg School of Public Health,undefined

[12] Johns Hopkins University,undefined

[13] Center for Chemical Dependency,undefined

[14] Johns Hopkins Medical Institutions,undefined

[15] PET Center and Center of Functionally Integrative Neuroscience,undefined

[16] Aarhus City Hospital,undefined

[17] Aarhus University Hospitals,undefined

[18] Aarhus University,undefined

[19] David Geffen School of Medicine at UCLA,undefined

[20] David Geffen School of Medicine at UCLA,undefined

[21] The Brain Research Institute,undefined

[22] David Geffen School of Medicine at UCLA,undefined

[23] Controlled Substance Staff,undefined

[24] Food and Drug Administration,undefined

[25] Intramural Research Program,undefined

[26] National Institute of Mental Health,undefined

[27] Discovery Medicine,undefined

[28] AstraZeneca LP,undefined

来源：

Neuropsychopharmacology | 2006年 / 31卷

关键词：

PET neuroimaging; cocaine; dopamine release; cue-elicited craving; receptor occupancy; dopamine receptors;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [11C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.

引用

页码：2716 / 2727

页数：11

共 48 条

[1] Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
Wong, Dean F.
Kuwabara, Hiroto
Schretlen, David J.
Bonson, Katherine R.
Zhou, Yun
Nandi, Ayon
Brasic, James R.
Kimes, Alane S.
Maris, Marika A.
Kumar, Anil
Contoreggi, Carlo
Links, Jonathan
Ernst, Monique
Rousset, Olivier
Zukin, Stephen
Grace, Anthony A.
Rohde, Charles
Jasinski, Donald R.
Gjedde, Albert
London, Edythe D.
NEUROPSYCHOPHARMACOLOGY, 2006, 31 (12) : 2716 - 2727
[2] Effects of naltrexone on cue-elicited craving for alcohol and cocaine
Modesto-Lowe, V
Burleson, JA
Hersh, D
Bauer, LO
Kranzler, HR
DRUG AND ALCOHOL DEPENDENCE, 1997, 49 (01) : 9 - 16
[3] Cannabis cue-elicited craving and the reward neurocircuitry
Filbey, Francesca M.
DeWitt, Samuel J.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2012, 38 (01) : 30 - 35
[4] Dopamine D1 and D3 receptors are differentially involved in cue-elicited cocaine seeking
Chen, Liping
Xu, Ming
JOURNAL OF NEUROCHEMISTRY, 2010, 114 (02) : 530 - 541
[5] A double-blind placebo-controlled pilot study of risperidone for decreasing cue-elicited craving in recently withdrawn cocaine dependent patients
Smelson, DA
Williams, J
Ziedonis, D
Sussner, BD
Losonczy, MF
Engelhart, C
Kaune, M
JOURNAL OF SUBSTANCE ABUSE TREATMENT, 2004, 27 (01) : 45 - 49
[6] Intranasal oxytocin dampens cue-elicited cigarette craving in daily smokers: a pilot study
Miller, Melissa A.
Bershad, Anya
King, Andrea C.
Lee, Royce
de Wit, Harriet
BEHAVIOURAL PHARMACOLOGY, 2016, 27 (08): : 697 - 703
[7] Cue-Elicited Affect and Craving: Advancement of the Conceptualization of Craving in Co-Occurring Posttraumatic Stress Disorder and Alcohol Dependence
Nosen, Elizabeth
Nillni, Yael I.
Berenz, Erin C.
Schumacher, Julie A.
Stasiewicz, Paul R.
Coffey, Scott F.
BEHAVIOR MODIFICATION, 2012, 36 (06) : 808 - 833
[8] Blockade of 5-HT2A receptors in the medial prefrontal cortex attenuates reinstatement of cue-elicited cocaine-seeking behavior in rats
Pockros, Lara A.
Pentkowski, Nathan S.
Swinford, Sarah E.
Neisewander, Janet L.
PSYCHOPHARMACOLOGY, 2011, 213 (2-3) : 307 - 320
[9] Sex-related differences in subjective, but not neural, cue-elicited craving response in heavy cannabis users
Prashad, Shikha
Hammonds, Ryan P.
Wiese, Amanda L.
Milligan, Amber L.
Filbey, Francesca M.
DRUG AND ALCOHOL DEPENDENCE, 2020, 209
[10] Altered prelimbic cortex output during cue-elicited drug seeking
Miller, CA
Marshall, JF
JOURNAL OF NEUROSCIENCE, 2004, 24 (31) : 6889 - 6897

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