Unrelated bone marrow transplantation for leukocyte adhesion deficiency

被引：0

作者：

NJ Farinha

M Duval

E Wagner

J Champagne

N Lapointe

S Barrette

B Tapiero

L Busque

MA Champagne

机构：

[1] Hôpital Sainte-Justine,Division of Hematology

[2] Hôpital Sainte-Justine,Oncology

[3] Hôpital Sainte-Justine,Division of Clinical Immunology

[4] Hôpital Maisonneuve-Rosemont,Division of Infectious Diseases, Department of Pediatrics

来源：

Bone Marrow Transplantation | 2002年 / 30卷

关键词：

bone marrow transplantation; unrelated; pediatric; leukocyte adhesion deficiency; immunodeficiency;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The severe form of leukocyte adhesion deficiency type I (LAD-I) usually leads to death early in life. Allogeneic haematopoietic transplantation is the only cure. Unrelated transplantation has been reported only once. We describe three children with LAD-I transplanted with T cell non-depleted bone marrow from unrelated HLA-matched donors. All patients engrafted, one of them at second transplant. One patient developed grade I and one grade II acute GVHD. Two patients are alive, one of them with a decrease in CD11/CD18 expression. Early referral for HLA-matched unrelated BMT is a reasonable option for patients with LAD-I lacking an HLA-matched related donor.

引用

页码：979 / 981

页数：2

共 27 条

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