Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness

被引：0

作者：

Hammerling M.J. ^{[1
]}

Ellefson J.W. ^{[1
]}

Boutz D.R. ^{[1
]}

Marcotte E.M. ^{[1
]}

Ellington A.D. ^{[1
]}

Barrick J.E. ^{[1
]}

机构：

[1] Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX

来源：

Nature Chemical Biology | 2014年 / 10卷 / 3期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nchembio.1450

中图分类号：

学科分类号：

摘要：

Bioengineering advances have made it possible to fundamentally alter the genetic codes of organisms. However, the evolutionary consequences of expanding an organism's genetic code with a noncanonical amino acid are poorly understood. Here we show that bacteriophages evolved on a host that incorporates 3-iodotyrosine at the amber stop codon acquire neutral and beneficial mutations to this new amino acid in their proteins, demonstrating that an expanded genetic code increases evolvability.

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页码：178 / 180

页数：2

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