Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness

被引：0

作者：

Hammerling M.J. ^{[1
]}

Ellefson J.W. ^{[1
]}

Boutz D.R. ^{[1
]}

Marcotte E.M. ^{[1
]}

Ellington A.D. ^{[1
]}

Barrick J.E. ^{[1
]}

机构：

[1] Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX

来源：

Nature Chemical Biology | 2014年 / 10卷 / 3期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1038/nchembio.1450

中图分类号：

学科分类号：

摘要：

Bioengineering advances have made it possible to fundamentally alter the genetic codes of organisms. However, the evolutionary consequences of expanding an organism's genetic code with a noncanonical amino acid are poorly understood. Here we show that bacteriophages evolved on a host that incorporates 3-iodotyrosine at the amber stop codon acquire neutral and beneficial mutations to this new amino acid in their proteins, demonstrating that an expanded genetic code increases evolvability.

引用

收藏

页码：178 / 180

页数：2

相关论文

共 50 条

[1] Bacteriophages use an expanded genetic code on evolutionary paths to higher fitness [J].

Hammerling, Michael J. ;

Ellefson, Jared W. ;

Boutz, Daniel R. ;

Marcotte, Edward M. ;

Ellington, Andrew D. ;

Barrick, Jeffrey E. .

NATURE CHEMICAL BIOLOGY, 2014, 10 (03) :178-+

[2] Evolving Bacterial Fitness with an Expanded Genetic Code [J].

Drew S. Tack ;

Austin C. Cole ;

Raghav Shroff ;

Barrett R. Morrow ;

Andrew D. Ellington .

Scientific Reports, 8

[3] Evolving Bacterial Fitness with an Expanded Genetic Code [J].

Tack, Drew S. ;

Cole, Austin C. ;

Shroff, Raghav ;

Morrow, Barrett R. ;

Ellington, Andrew D. .

SCIENTIFIC REPORTS, 2018, 8

[4] Bacteria use expanded genetic code [J].

Borman, Stu .

CHEMICAL & ENGINEERING NEWS, 2017, 95 (48) :5-5

[5] Genetic Paths to Evolutionary Rescue and the Distribution of Fitness Effects Along Them [J].

Osmond, Matthew M. ;

Otto, Sarah P. ;

Martin, Guillaume .

GENETICS, 2020, 214 (02) :493-510

[6] An expanded genetic code [J].

Schultz, P .

BIOPOLYMERS, 2005, 80 (04) :489-489

[7] Inclusion of the fitness sharing technique in an evolutionary algorithm to analyze the fitness landscape of the genetic code adaptability [J].

Santos, Jose ;

Monteagudo, Angel .

BMC BIOINFORMATICS, 2017, 18

[8] Inclusion of the fitness sharing technique in an evolutionary algorithm to analyze the fitness landscape of the genetic code adaptability [J].

José Santos ;

Ángel Monteagudo .

BMC Bioinformatics, 18

[9] GENETIC AND EVOLUTIONARY FITNESS [J].

MURPHY, EA .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1978, 2 (01) :51-79

[10] A family of bacteriophages uses an expanded genetic alphabet [J].

Kaminski, Pierre-Alexandre .

M S-MEDECINE SCIENCES, 2022, 38 (04) :374-380

← 1 2 3 4 5 →