Cannabis and Mood Disorders

被引:29
|
作者
Lucatch A.M. [1 ]
Coles A.S. [1 ]
Hill K.P. [2 ]
George T.P. [1 ,3 ]
机构
[1] Addictions Division, Centre for Addictions and Mental Health (CAMH), 100 Stokes Street, BGB 3288, Toronto, MJ6 1H4, ON
[2] Division of Addiction Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
[3] Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, ON
基金
加拿大健康研究院;
关键词
Antidepressants; Bipolar disorder; Cannabis; Cannabis use disorder; Major depression; Mood; Mood disorders; Stabilizers;
D O I
10.1007/s40429-018-0214-y
中图分类号
学科分类号
摘要
Purpose of Review: The present review will provide an overview of the neurobiology, epidemiology, clinical impact, and treatment of cannabis use disorder (CUD) in mood disorders. Recent Findings: Patients with mood disorders including major depressive disorder (MDD) and bipolar disorder (BD) have higher rates of cannabis use, and CUD compared to the general population. Reasons for this association are not clear, nor are the putative therapeutic effects of cannabis use, or its components delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), in these illnesses. The evidence surrounding treatments for patients with this comorbidity is lacking, with more support for psychotherapeutic treatments compared with pharmacological treatments. Summary: Cannabis use may be associated with mood disorders, but more research is needed to increase our understanding of the mechanisms for this association, and to develop more effective treatments for this comorbidity. © 2018, Springer International Publishing AG, part of Springer Nature.
引用
收藏
页码:336 / 345
页数:9
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