Strength of the Evidence: Adjuvant Therapy for Resected Pancreatic Cancer

被引：0
作者：
Vincent J. Picozzi
Peter W. T. Pisters
Selwyn M. Vickers
Steven M. Strasberg
机构：
[1] Virginia Mason Medical Center,Section of Medical Oncology
[2] Barnes Hospital,Section of General Surgery
[3] MD Anderson Hospital,Section of Surgical Oncology
[4] University of Minnesota,Deparment of Surgery
来源：
Journal of Gastrointestinal Surgery | 2008年 / 12卷
关键词：
Pancreatic cancer; Adjuvant therapy; Postgraduate course; Pancreatic neoplasms;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pancreatic cancer remains one of the greatest challenges within oncology. Among resected patients, 5-year survival is typically only 10–25%. Among eight major randomized trials for resected pancreas cancer, five (GITSG, EORTC, ESPAC-1, RTOG 9704, and CONKO-1), containing a total of over 1,200 patients, have shaped world opinion on this subject. These trials have many significant methodological differences. Major conclusions that can be drawn from these trials in composite are (1) adjuvant chemotherapy is superior to observation following pancreaticoduodenectomy for pancreatic cancer, (2) gemcitabine is superior to 5-FU as adjuvant chemotherapy, and (3) the benefit of adjuvant chemoradiation is uncertain. Additional randomized trials are needed to address significant areas of controversy within available data.
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页码：657 / 661
页数：4
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