Sinonasal Neuroendocrine Neoplasms: Current Challenges and Advances in Diagnosis and Treatment, with a Focus on Olfactory Neuroblastoma

被引：33
作者：
Bell D. [1 ]
机构：
[1] Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX
来源：
Head and Neck Pathology | 2018年 / 12卷 / 1期
关键词：
Olfactory neuroblastoma; Sinonasal large cell carcinoma; Sinonasal neuroendocrine tumors; Sinonasal small cell carcinoma;
D O I：
10.1007/s12105-018-0887-5
中图分类号：
学科分类号：
摘要：
Sinonasal tumors with neuroendocrine differentiation form a group of rare heterogeneous neoplasms of neuroectodermal and epithelial origin, consisting of olfactory neuroblastomas and neuroendocrine carcinomas. Because the natural history and biological behavior of this group of tumors vary, the morphological diagnosis coupled with grading/staging is important for prognostication, and the approach to treatment and rehabilitation is multidisciplinary. The identification of molecular abnormalities underlying these tumors is critical to the development of specific targeted therapies and the design of clinical trials. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
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收藏
页码：22 / 30
页数：8
相关论文
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