Effect of cultivation conditions on production of secondary metabolites by Penicillium citrinum

被引：0
作者：
T. V. Antipova
V. P. Zhelifonova
A. G. Kozlovsky
机构：
[1] Russian Academy of Sciences,Skryabin Institute of Biochemistry and Physiology of Microorganisms
来源：
Microbiology | 2015年 / 84卷
关键词：
fungi; Penicillium citrinum; ergot alkaloids; quinocitrinines; formation; secondary metabolites;
D O I：
暂无
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学科分类号：
摘要：
Medium composition, cultivation temperature, and pO2 had a regulatory effect on production of ergot alkaloids (EA) and quinocitrinines (QC) by the fungal strain Penicillium citrinum VKM F-4043 D. Maximal accumulation of EA and QC occurred at 24 and 28°C, respectively. Maximal EA synthesis occurred at 40% pO2, while at 10–20% the conditions were optimal for QC synthesis. Production of these metabolites depended directly on the concentration of the carbon source in the medium. Addition of 2.5% NaCl did not inhibit EA and QC accumulation.
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页码：365 / 369
页数：4
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