Neurodegenerative Changes in Rat Brain in Streptozotocin Model of Alzheimer’s Disease

被引：0
作者：
D. N. Voronkov
A. V. Stavrovskaya
E. V. Stelmashook
E. E. Genrikhs
N. K. Isaev
机构：
[1] Research Center of Neurology,A. N. Belozersky Institute of Physico
[2] M. V. Lomonosov Moscow State University,Chemical Biology
来源：
Bulletin of Experimental Biology and Medicine | 2019年 / 166卷
关键词：
streptozotocin; Alzheimer’s disease; PSA-NCAM;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
One of the most common models of sporadic form of Alzheimer’s disease is injection of streptozotocin into the lateral ventricles of rat brain. In 3 months after this injection, an increase in the expression of astroglia in the corpus callosum and a decrease in the thickness of the corpus callosum and intensity of its staining with luxol fast blue were observed. This can reflect a decrease in the content of myelinated fibers. In layer V of the sensorimotor cortex, intensive degeneration of neurons was revealed. The lateral ventricles were significantly enlarged and the expression of PSA-NCAM protein, a marker of immature neurons, was reduced in subventricular zone, which can be associated with disturbed neurogenesi
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页码：793 / 796
页数：3
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