Non-lethal outcomes of engaging regulated cell death pathways in cancer

被引：0
作者：
Halime Kalkavan
Sebastian Rühl
Jeremy J. P. Shaw
Douglas R. Green
机构：
[1] St Jude Children’s Research Hospital,Department of Immunology
[2] University Hospital Essen,West German Cancer Center, Department of Medical Oncology
[3] Partner Site University Hospital Essen,German Cancer Consortium (DKTK)
[4] T3 Pharmaceuticals AG,undefined
来源：
Nature Cancer | 2023年 / 4卷
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学科分类号：
摘要：
Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the engagement of RCD pathways does not inevitably result in cell death. Instead, RCD pathways can take part in diverse biological processes if the cells survive. Consequently, these surviving cells, for which we propose the term ‘flatliners’, harbor important functions. These evolutionarily conserved responses can be exploited by cancer cells to promote their own survival and growth, with challenges and opportunities for cancer therapy.
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页码：795 / 806
页数：11
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