Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial

被引:0
作者
Michael T. Hawkes
Andrea L. Conroy
Robert O. Opoka
Laura Hermann
Kevin E. Thorpe
Chloe McDonald
Hani Kim
Sarah Higgins
Sophie Namasopo
Chandy John
Chris Miller
W. Conrad Liles
Kevin C. Kain
机构
[1] University of Alberta,3
[2] University of Toronto,588D Edmonton Clinic Health Academy
[3] Mulago Hospital,Sandra Rotman Centre for Global Health, MaRS Centre
[4] St Michael’s Hospital,Global Health Uganda, Upper Paediatrics Office
[5] International Vaccine Access Center,Applied Health Research Centre
[6] Jinja Regional Referral Hospital,Johns Hopkins School of Public Health
[7] Indiana University,Department of Pediatrics
[8] University of British Columbia,Division of Infectious Disease
[9] Rm D433,Department of Medicine
[10] HP East,undefined
[11] Vancouver Hospital,undefined
[12] University of Washington,undefined
来源
Malaria Journal | / 14卷
关键词
Nitric oxide; Endothelium; Severe malaria; Child; Randomized controlled trial;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 158 条
[1]  
Murray CJ(2012)Global malaria mortality between 1980 and 2010: a systematic analysis Lancet 379 413-431
[2]  
Rosenfeld LC(2009)Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review Bull World Health Organ 87 896-904
[3]  
Lim SS(2011)Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale Med Hypotheses 77 437-444
[4]  
Andrews KG(2011)Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria PLoS One 6 e27714-2695
[5]  
Foreman KJ(2005)Inhaled nitric oxide therapy in adults N Engl J Med 353 2683-1660
[6]  
Haring D(2003)Anti-adhesive effect of nitric oxide on Plasmodium falciparum cytoadherence under flow Am J Pathol 162 1651-4156
[7]  
Kyu HH(2004)The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies Blood 103 4150-239
[8]  
Fernandez E(2006)Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation Nat Med 12 235-959
[9]  
Hawkes M(2012)Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study Crit Care Med 40 952-17102
[10]  
Opoka RO(2011)Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study PLoS One 6 e17440-150