Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

被引：0

作者：

Takashi Shichita

Yuki Sugiyama

Hiroaki Ooboshi

Hiroshi Sugimori

Ryusuke Nakagawa

Ichiro Takada

Toru Iwaki

Yasunori Okada

Mitsuo Iida

Daniel J Cua

Yoichiro Iwakura

Akihiko Yoshimura

机构：

[1] School of Medicine,Department of Microbiology and Immunology

[2] Keio University,Division of Molecular and Cellular Immunology

[3] Shinjuku-ku,Department of Medicine and Clinical Science

[4] Medical Institute of Bioregulation,Department of Internal Medicine

[5] Kyushu University,Department of Neuropathology

[6] Graduate School of Medical Sciences,Department of Pathology

[7] Kyushu University,Department of Immunology

[8] Fukuoka Dental College Medical and Dental Hospital,Center for Experimental Medicine and Department of Cancer Biology

[9] Graduate School of Medical Sciences,undefined

[10] Kyushu University,undefined

[11] School of Medicine,undefined

[12] Keio University,undefined

[13] Shijuku-ku,undefined

[14] Schering-Plough,undefined

[15] Institute of Medical Science,undefined

[16] University of Tokyo,undefined

[17] Japan Science and Technology Agency,undefined

[18] Core Research for Evolutional Science and Technology (CREST),undefined

来源：

Nature Medicine | 2009年 / 15卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Inflammatory cells invade the brain after stroke, but their role in disease has been unclear. Now, Akihiko Yoshimura and colleagues report that a particular population of T cells that express the inflammatory cytokine IL-17 plays a key role in stroke progression: depletion of these cells—even as late as 1 day after stroke—can alleviate brain injury in mice pages 844–846).

引用

页码：946 / 950

页数：4

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