DTaP-IPV/Hib vaccine (Pentacel®)

被引：14
作者：
Dhillon S. [1 ,2 ,3 ]
Keam S.J. [1 ,2 ]
机构：
[1] Wolters Kluwer Health / Adis, Auckland
[2] Wolters Kluwer Health, Conshohocken, PA
[3] Wolters Kluwer Health / Adis, Mairangi Bay, North Shore 0754, Auckland
来源：
Pediatric Drugs | 2008年 / 10卷 / 6期
关键词：
Adis Drug Profiles; Diphtheria; Pertussis; Poliomyelitis; Tetanus;
D O I：
10.2165/0148581-200810060-00008
中图分类号：
学科分类号：
摘要：
▲ The combination vaccine diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and Haemophilus b conjugate (tetanus toxoid conjugate) vaccine (DTaP-IPV/Hib), which has been exclusively used in Canada for more than 10 years, is the first DTaP-based vaccine approved in the US that includes both poliovirus and Haemophilus influenzae type b (Hib) antigens. ▲ In clinical trials, the combined DTaP-IPV/Hib vaccine induced high immunogenecity against all of the vaccine antigens, including Hib. ▲ Administration of the DTaP-IPV/Hib vaccine as a four-dose series in infants provided high levels of seroprotection against diphtheria and tetanus toxoids, poliovirus types 1, 2, and 3, and Hib polyribosyl-ribitol-phosphate capsular polysaccharide conjugated to tetanus toxoid (PRP-T). Immune responses produced after doses 3 and 4 of DTaP-IPV/Hib vaccine were noninferior to those seen with separately administered DTaP, inactivated poliovirus, and Hib vaccines, apart from those against PRP-T in one study. ▲ Seroconversion rates for the five pertussis components in DTaP-IPV/Hib vaccine were noninferior to those seen in infants receiving the separately administered vaccines. A serology bridging study showed the noninferiority of four doses of DTaP-IPV/Hib vaccine to three doses of a DTaP vaccine in terms of seroconversion rates for filamentous hemagglutinin and fimbriae 2 and 3, but not pertactin. ▲ There were no clinically relevant changes in the immunogenicity of DTaP-IPV/Hib when coadministered with pneumococcal-7-valent-CRM197 vaccine or measles, mumps, and rubella vaccine and varicella zoster vaccine at 15 months. ▲ The tolerability profile of DTaP-IPV/Hib vaccine was generally similar to that of separately administered DTaP, IPV, and Hib vaccines.Table. Features and properties of the diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and haemophilus b conjugate (tetanus toxoid conjugate) vaccine. © 2008 Adis Data Information BV. All rights reserved.
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页码：405 / 416
页数：11
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