Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3H)-one

被引：0
作者：
I. A. Novakov
A. S. Yablokov
B. S. Orlinson
M. B. Navrotskii
I. A. Kirillov
A. A. Vernigora
A. S. Babushkin
V. V. Kachala
D. Schols
机构：
[1] Volgograd State Technical University,Zelinskii Institute of Organic Chemistry
[2] Russian Academy of Sciences,undefined
[3] Rega Institute for Medical Research,undefined
来源：
Russian Journal of Organic Chemistry | 2016年 / 52卷
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摘要：
Based on 2-(2,6-difluorophenyl)acetonitrile a synthesis was performed of new bioisosteric prochiral analogs of anti-HIV-1 active derivatives of 2-alkoxy-6-benzylpyrimidin-4(3Н)-one that we had previously obtained. The study using infected and nonifected strains of cells MT-4 made it possible to find in all prepared compounds a high anti-HIV activity whereas the cytotoxicity of the substances depended strongly on the structure of the alkylsulfanyl fragment of the molecule.
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页码：1188 / 1193
页数：5
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