Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

被引：0
作者：
A. Gomez
J. Gomez
M. Lopez Torres
A. Naudi
N. Mota-Martorell
R. Pamplona
G. Barja
机构：
[1] Complutense University of Madrid (UCM),Department of Animal Physiology
[2] University of Lleida-IRBLLEIDA,II, Faculty of Biological Sciences
[3] Universidad Complutense,Department of Experimental Medicine, Faculty of Medicine
来源：
Journal of Bioenergetics and Biomembranes | 2015年 / 47卷
关键词：
Cysteine; Radicals; Mitochondria; Restriction; Methionine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
It has been described that dietary cysteine reverses many of the beneficial changes induced by methionine restriction in aging rodents. In this investigation male Wistar rats were subjected to diets low in methionine, supplemented with cysteine, or simultaneously low in methionine and supplemented with cysteine. The results obtained in liver showed that cysteine supplementation reverses the decrease in mitochondrial ROS generation induced by methionine restriction at complex I. Methionine restriction also decreased various markers of oxidative and non-oxidative stress on mitochondrial proteins which were not reversed by cysteine. Instead, cysteine supplementation also lowered protein damage in association with decreases in mTOR activation. The results of the present study add the decrease in mitochondrial ROS production to the various beneficial changes induced by methionine restriction that are reversed by cysteine dietary supplementation.
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页码：199 / 208
页数：9
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