Contribution of the renin-angiotensin system to the intrarenal resistive index in chronic unilateral partial ureteral obstruction in dogs

被引：0

作者：

Yokoyama H. ^{[1
]}

Tsuji Y. ^{[2
]}

机构：

[1] Department of Urology, Fukuoka University, School of Medicine, Jonan-ku, Fukuoka 814-0180

[2] Tenjin Tsuji Clinic, Fukuoka

来源：

Journal of Medical Ultrasonics | 2005年 / 32卷 / 3期

关键词：

Doppler ultrasonography; Renin-angiotensin system; Resistive index; Ureteral obstruction;

D O I：

10.1007/s10396-005-0044-0

中图分类号：

学科分类号：

摘要：

Purpose. We investigated the role of the renin-angiotensin system on intrarenal hemodynamics in chronic unilateral partial ureteral obstruction (UPUO) using Doppler ultrasound (US). Methods. In 11 dogs with chronic UPUO, we determined the renal resistive index (RI) before and 1∈h after the intravenous infusion of an angiotensin-converting enzyme (ACE) inhibitor (captopril), an angiotensin II receptor type 1 (ART1) antagonist (L-158,809), and the combination of these two drugs. Change in resistive index (ΔRI) was calculated as RI after the administration of each tested material minus baseline RI. Results. At the baseline measurement, significant differences in RI were seen between obstructed and nonobstructed kidneys. ACE inhibitor, ART1 antagonist, or the combination of these drugs did not result in any significant changes in RI in either obstructed or nonobstructed kidneys. However, in obstructed kidneys, ΔRI in the combination of ACE inhibitor and ART1 antagonist were significantly greater than those in ACE inhibitor or ART1 antagonist alone, whereas there were no significant differences in those values in nonobstructed kidneys. Conclusion. These observations suggest that the renin-angiotensin system in dogs with chronic UPUO may not contribute significantly to the differences in intrarenal RI between obstructed and nonobstructed kidneys. However, the angiotensin-producing pathways and angiotensin II receptor subtypes other than ACE and ART1 may have some different effects between obstructed and nonobstructed kidneys. © The Japan Society of Ultrasonics in Medicine 2005.

引用

页码：101 / 105

页数：4

共 31 条

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