Dynamic Analysis of Changes of Protein Levels and Selected Biochemical Indices in Rat Serum in the Course of Experimental Pleurisy

被引：0
作者：
Ireneusz Całkosiński
Jacek Majda
Grzegorz Terlecki
Kinga Gostomska-Pampuch
Katarzyna Małolepsza-Jarmołowska
Sylwia Sobolewska
Aleksandra Całkosińska
Aleksandra Kumala
Andrzej Gamian
机构：
[1] Wroclaw Medical University,Independent Laboratory of Neurotoxicology and Environmental Diagnostics
[2] 4th Military Hospital,Department of Laboratory Diagnostics
[3] Wroclaw Medical University,Department of Medical Biochemistry
[4] Polish Academy of Sciences,Institute of Immunology and Experimental Therapy
[5] Wroclaw Medical University,Department of Drugs Form Technology
[6] Wroclaw University of Environmental and Life Sciences,Department of Animal Nutrition and Feed Management
来源：
Inflammation | 2016年 / 39卷
关键词：
pleurisy; inflammatory reaction; electrophoresis of serum proteins; acute-phase proteins;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A significant role is played in inflammation by the liver, which, stimulated by inflammatory mediators, synthetizes plasma proteins with various dynamics. The purpose of these studies is to generate a detailed dynamic analysis of changes to concentrations of plasma and serum protein fractions and selected acute-phase proteins as well as nonspecific biochemical indices during the course of an induced pleurisy. The studies were conducted on female inbred Buffalo rats, which were divided into two groups: a control group (C) and an experimental group (IP) in which pleurisy was induced. In the IP group, significant changes in biochemical indices were observed between the 48th and 96th hours of pleurisy. A reduction of albumin, transferrin, urea, and creatinine concentrations was observed, while concentrations of the complement components C3 and C4, haptoglobin, and fibrinogen increased. An early increase of IL-1 was observed, while increases of IL-6 and TNF were noted in the later period. The maximum intensity of the processes described above occurred between the 72nd and 96th hours of pleurisy.
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页码：1076 / 1089
页数：13
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