Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia

被引：0
|
作者：
O. V. Povarova
A. V. Balatsky
V. S. Gusakov
O. S. Medvedev
机构：
[1] Faculty of Fundamental Medicine,Medical Research and Educational Center
[2] M. V. Lomonosov Moscow State University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 165卷
关键词：
neuroprotection; local cerebral ischemia; UbiAd1 gene expression; coenzyme Q10;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral artery in the left hemisphere. Ischemia enhanced expression of mRNA of UbiAd1 gene in both cerebral hemispheres, but the effect was significant only in the contralateral one. The study revealed no effect of intraperitoneal injection of coenzyme Q10 (30 mg/kg) on ischemia-produced elevation of mRNA of UbiAd1 gene. Further studies are needed to assess possible neuroprotective effects of antioxidant coenzyme Q10.
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页码：69 / 71
页数：2
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