Design of SiO2/aminopropylsilane-modified magnetic Fe3O4 nanoparticles for doxorubicin immobilization

被引：0
作者：
A. M. Demin
A. V. Vakhrushev
M. S. Valova
A. S. Minin
D. K. Kuznetsov
M. A. Uimin
V. Ya. Shur
V. P. Krasnov
V. N. Charushin
机构：
[1] Ural Branch of the Russian Academy of Sciences,I. Ya. Postovsky Institute of Organic Synthesis
[2] Ural Branch of the Russian Academy of Sciences,Mikheev Institute of Metal Physics
[3] Ural Federal University,Institute of Natural Sciences and Mathematics
[4] Ural Federal University named after the first President of Russia B. N. Yeltsin,Institute of Chemical Engineering
来源：
Russian Chemical Bulletin | 2021年 / 70卷
关键词：
Fe; O; magnetic nanoparticles; -phosphonomethyliminodiacetic acid; SiO; coating; doxorubicin; sorption;
D O I：
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中图分类号：
学科分类号：
摘要：
Surface modification of magnetic nanoparticles (MNPs) with tetramethylorthosilicate and 3-aminopropyltrimethoxysilane was studied. The use of N-phosphonomethyliminodiacetic acid for the stabilization of the initial MNPs can significantly increase the coating thickness and specific surface area of SiO2/APS-modified (APS is 3-aminopropylsilane) MNPs. The possibility of sorption of antitumor drug doxorubicin (DOX) on the synthesized nanoparticles was studied. The degree of sorption of DOX increases with an increase in the specific surface area of the particles.
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页码：987 / 994
页数：7
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