Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

被引：0
作者：
Krista L Moulder
B Joy Snider
Susan L Mills
Virginia D Buckles
Anna M Santacruz
Randall J Bateman
John C Morris
机构：
[1] Washington University School of Medicine,Department of Neurology
来源：
Alzheimer's Research & Therapy | / 5卷
关键词：
Mild Cognitive Impairment; Mutation Carrier; Secondary Prevention Trial; Asymptomatic Mutation Carrier; Clinical Trial Committee;
D O I：
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学科分类号：
摘要：
The Dominantly Inherited Alzheimer Network (DIAN) is an international registry of individuals at risk for developing autosomal dominant Alzheimer’s disease (AD). Its primary aims are to investigate the temporal ordering of AD pathophysiological changes that occur in asymptomatic mutation carriers and to identify those markers that herald the transition from cognitive normality to symptomatic AD. DIAN participants undergo longitudinal evaluations, including clinical and cognitive assessments and measurements of molecular and imaging AD biomarkers. This review details the unique attributes of DIAN as a model AD biomarker study and how it provides the infrastructure for innovative research projects, including clinical trials. The recent design and launch of the first anti-amyloid-beta secondary prevention trial in AD, led by the related DIAN Trials Unit, also are discussed.
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