Decreased cerebrospinal fluid levels of β-endorphin and ACTH in children with infantile spasms

被引：0

作者：

S. Nagamitsu

T. Matsuishi

Y. Yamashita

T. Shimizu

R. Iwanaga

Y. Murakami

M. Miyazaki

T. Hashimoto

H. Kato

机构：

[1] Department of Pediatrics and Child Health,

[2] Kurume University School of Medicine,undefined

[3] Kurume,undefined

[4] ,undefined

[5] Department of Pediatrics,undefined

[6] School of Medicine,undefined

[7] University of Tokushima,undefined

[8] Tokushima,undefined

[9] and,undefined

[10] Division of Clinical Psychology and Counselling Service,undefined

[11] National Center Hospital for Mental,undefined

[12] Nervous and Muscular Disorders,undefined

[13] Tokyo,undefined

[14] Japan,undefined

来源：

Journal of Neural Transmission | 2001年 / 108卷

关键词：

Keywords: Infantile spasms; β-endorphin; ACTH; CRH; brain-adrenal axis.;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

To investigate the pathophysiology of infantile spasms (IS), we measured the cerebrospinal fluid (CSF) levels of β-endorphin (β-EP), adrenocorticotropic hormone (ACTH), and corticotropin-releasing hormone (CRH) in 20 patients with IS, including 11 with the secondary form and 9 with the cryptogenic form of the disease. The findings were compared with those obtained in age-matched controls without neurologic disease. The CSF levels of β-EP and ACTH were significantly lower in patients with IS than those in the controls. The CSF levels of CRH in patients with IS were lower, although, this trend was not significant.

引用

页码：363 / 371

页数：8

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[1] Decreased cerebrospinal fluid levels of β-endorphin and ACTH in children with infantile spasms
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