Long-term results of breast conserving surgery for stages i and II breast cancer: Experiences at osaka medical center for cancer and cardiovascular diseases

被引：5
作者：
Komoike Y. [1 ]
Motomura K. [1 ]
Inaji H. [1 ]
Kasugai T. [2 ]
Nose T. [3 ]
Koizumi M. [3 ]
Koyama H. [1 ]
机构：
[1] Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinan-ku, Osaka 537 8511
[2] Department of Radiation Oncology, Osaka Medical Centerfor Cancer and Cardiovascubr Diseases
来源：
Breast Cancer | 2002年 / 9卷 / 3期
关键词：
Breast cancer; Breast-conserving surgery; Local recurrence; Risk factor;
D O I：
10.1007/BF02967597
中图分类号：
学科分类号：
摘要：
Purpose: The purpose of this study is to summarize the long-term results of breast conserving surgery (BCS) for Japanese patients with stage I and I] breast cancer at a single institute and to identify risk factors for local recurrence after BCS. Patients and Methods: Between October 1986 and June 2000, 979 women underwent BCS with or without radiation therapy (RT). Overall survival, disease free survival and local recurrence rates were calculated by the Kaplan-Meier method. Risk factors for local recurrence were examined by multivariate analysis using the Cox proportional regression model. Results: The 10-year overall survival rates were 90.9% for the surgery and radiation therapy (RT group) and 89.3% for the surgery only group with a median follow-up time of 46 months. The 10-year disease free survival rates were 85.1% in the RT group and 69.2% in the surgery only group (p = 0.0001). The positive margin rate was 14.1% (138/979). The 10-year overall survival rate of the patients with positive margins was 87.9%, compared with 90.8% for patients with negative margins (N.S.). The cumulative incidence of local recurrence at 10 years was significantly lower in the RT group (7.2%) than in the surgery only group (27.5%) (p < 0.0001). Multivariate analysis showed that positive margins and lack of post-operative irradiation or adjuvant endocrine therapy were risk factors for non-inflammatory local recurrence. Conclusions: Our study indicates that BCS can be performed for Japanese women with early breast cancer. The margin status and post-operative irradiation had no influence on overall survival while but were significantly related to local recurrence. Breast Cancer 9:248-253, 2002.
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页码：248 / 253
页数：5
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