Cholinergic modulation of a specific memory function of prefrontal cortex
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作者:
Paula L Croxson
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机构:Glickenhaus Laboratory of Neuropsychology and Friedman Brain Institute,Department of Neuroscience
Paula L Croxson
Diana A Kyriazis
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机构:Glickenhaus Laboratory of Neuropsychology and Friedman Brain Institute,Department of Neuroscience
Diana A Kyriazis
Mark G Baxter
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机构:Glickenhaus Laboratory of Neuropsychology and Friedman Brain Institute,Department of Neuroscience
Mark G Baxter
机构:
[1] Glickenhaus Laboratory of Neuropsychology and Friedman Brain Institute,Department of Neuroscience
[2] Mount Sinai School of Medicine,Department of Experimental Psychology
[3] Oxford University,undefined
来源:
Nature Neuroscience
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2011年
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14卷
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摘要:
Deficits in prefrontal cholinergic function have been implicated in cognitive impairment in many neuropsychiatric diseases. Here, the authors report that monkeys with lesions of cholinergic input to prefrontal cortex were impaired on a spatial working memory task, but not on other tests of cognitive function that also require intact prefrontal cortex.
机构:
Mt Sinai Sch Med, Dept Neurosci, Glickenhaus Lab Neuropsychol, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Neurosci, Friedman Brain Inst, New York, NY USA
Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, EnglandMt Sinai Sch Med, Dept Neurosci, Glickenhaus Lab Neuropsychol, New York, NY 10029 USA
Croxson, Paula L.
Kyriazis, Diana A.
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机构:
Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, EnglandMt Sinai Sch Med, Dept Neurosci, Glickenhaus Lab Neuropsychol, New York, NY 10029 USA
Kyriazis, Diana A.
Baxter, Mark G.
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机构:
Mt Sinai Sch Med, Dept Neurosci, Glickenhaus Lab Neuropsychol, New York, NY 10029 USA
Mt Sinai Sch Med, Dept Neurosci, Friedman Brain Inst, New York, NY USA
Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, EnglandMt Sinai Sch Med, Dept Neurosci, Glickenhaus Lab Neuropsychol, New York, NY 10029 USA
机构:
George Washington Univ, Sch Med & Hlth Sci, Dept Physiol & Pharmacol, Washington, DC 20037 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Physiol & Pharmacol, Washington, DC 20037 USA
Boyle, Natalie
Betts, Sarah
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机构:
George Washington Univ, Sch Med & Hlth Sci, Dept Physiol & Pharmacol, Washington, DC 20037 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Physiol & Pharmacol, Washington, DC 20037 USA
Betts, Sarah
Lu, Hui
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机构:
George Washington Univ, Sch Med & Hlth Sci, Dept Physiol & Pharmacol, Washington, DC 20037 USAGeorge Washington Univ, Sch Med & Hlth Sci, Dept Physiol & Pharmacol, Washington, DC 20037 USA