Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

被引:0
|
作者
Takashi Satoh
Hiroyasu Kidoya
Hisamichi Naito
Masahiro Yamamoto
Naoki Takemura
Katsuhiro Nakagawa
Yoshichika Yoshioka
Eiichi Morii
Nobuyuki Takakura
Osamu Takeuchi
Shizuo Akira
机构
[1] Laboratory of Host Defense,Department of Host Defense
[2] WPI Immunology Frontier Research Center (WPI IFReC),Department of Signal Transduction
[3] Osaka University,Department of Immunoparasitology
[4] 3-1 Yamada-oka,Department of Pathology
[5] Suita,undefined
[6] Osaka 565-0871,undefined
[7] Japan ,undefined
[8] Research Institute for Microbial Diseases (RIMD),undefined
[9] Osaka University,undefined
[10] 3-1 Yamada-oka,undefined
[11] Suita,undefined
[12] Osaka 565-0871,undefined
[13] Japan,undefined
[14] Research Institute for Microbial Diseases (RIMD),undefined
[15] Osaka University,undefined
[16] 3-1 Yamada-oka,undefined
[17] Suita,undefined
[18] Osaka 565-0871,undefined
[19] Japan,undefined
[20] Laboratory of immunoparasitology,undefined
[21] WPI Immunology Frontier Research Center (WPI IFReC),undefined
[22] Osaka University,undefined
[23] 3-1 Yamada-oka,undefined
[24] Suita,undefined
[25] Osaka 565-0871,undefined
[26] Japan ,undefined
[27] Research Institute for Microbial Diseases (RIMD),undefined
[28] Osaka University,undefined
[29] 3-1 Yamada-oka,undefined
[30] Suita,undefined
[31] Osaka 565-0871,undefined
[32] Japan,undefined
[33] Laboratory of Biofunctional Imaging,undefined
[34] WPI Immunology Frontier Research Center (WPI IFReC),undefined
[35] Osaka University,undefined
[36] 3-1 Yamada-oka,undefined
[37] Suita,undefined
[38] Osaka 565-0871,undefined
[39] Japan ,undefined
[40] Graduate School of Medicine,undefined
[41] Osaka University,undefined
[42] 2-2 Yamada-oka,undefined
[43] Suita,undefined
[44] Osaka 565-0871,undefined
[45] Japan,undefined
[46] Laboratory of Infection and Prevention,undefined
[47] Institute for Virus Research,undefined
[48] Kyoto University,undefined
[49] 53 Shogoin Kawara-cho,undefined
[50] Sakyo-ku,undefined
来源
Nature | 2013年 / 495卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Haematopoietic expression of the adaptor protein Trib1 is shown to be required for the presence of adipose-tissue-resident macrophages with an M2-like phenotype; Trib1 deficiency leads to aberrant expression of C/EBPα and impaired adipose tissue function.
引用
收藏
页码:524 / 528
页数:4
相关论文
共 50 条
  • [41] Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype
    Ieronymaki, Eleftheria
    Theodorakis, Emmanouel M.
    Lyroni, Konstantina
    Vergadi, Eleni
    Lagoudaki, Eleni
    Al-Qahtani, Ahmed
    Aznaourova, Marina
    Neofotistou-Themeli, Elpida
    Eliopoulos, Aristides G.
    Vaporidi, Katerina
    Tsatsanis, Christos
    JOURNAL OF IMMUNOLOGY, 2019, 202 (06): : 1786 - 1797
  • [42] Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury
    Iwai, Haruki
    Ataka, Koji
    Suzuki, Hajime
    Dhar, Ashis
    Kuramoto, Eriko
    Yamanaka, Atsushi
    Goto, Tetsuya
    JOURNAL OF NEUROINFLAMMATION, 2021, 18 (01)
  • [43] Going Full TeRM: The Seminal Role of Tissue-Resident Macrophages in Organ Remodeling during Pregnancy and Lactation
    Wu, Yixuan
    Chean, Ye
    Zhen, Shu
    JOURNAL OF IMMUNOLOGY, 2024, 212 (04): : 513 - 521
  • [44] Peritoneal resident macrophages in mice with MLL-AF9-induced acute myeloid leukemia show an M2-like phenotype
    Chen, Chong
    Wang, Rong
    Feng, Wenli
    Yang, Feifei
    Wang, Lina
    Yang, Xiao
    Ren, Li
    Zheng, Guoguang
    ANNALS OF TRANSLATIONAL MEDICINE, 2021, 9 (03)
  • [45] Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue
    Yi-Na Wang
    Yan Tang
    Zhihui He
    Hong Ma
    Linyuan Wang
    Yang Liu
    Qiqi Yang
    Dongning Pan
    Cuiqing Zhu
    Shuwen Qian
    Qi-Qun Tang
    Nature Metabolism, 2021, 3 : 1536 - 1551
  • [46] MiR-98-5p expression inhibits polarization of macrophages to an M2 phenotype by targeting Trib1 in inflammatory bowel disease
    Peng, Yunhua
    Wang, Qingyuan
    Yang, Wei
    Yang, Qiqi
    Pei, Ynani
    Zhang, Wei
    ACTA BIOCHIMICA POLONICA, 2020, 67 (02) : 157 - 163
  • [47] Critical role of synovial tissue-resident macrophage niche in joint homeostasis and suppression of chronic inflammation
    Huang, Qi-Quan
    Doyle, Renee
    Chen, Shang-Yang
    Sheng, Qicong
    Misharin, Alexander, V
    Mao, Qinwen
    Winter, Deborah R.
    Pope, Richard M.
    SCIENCE ADVANCES, 2021, 7 (02)
  • [48] FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma
    Chung, Sangwoon
    Kim, Ji Y.
    Song, Min-Ae
    Park, Gye Y.
    Lee, Yong G.
    Karpurapu, Manjula
    Englert, Joshua A.
    Ballinger, Megan N.
    Pabla, Navjot
    Chung, Hae Y.
    Christman, John W.
    ALLERGY, 2019, 74 (03) : 535 - 548
  • [49] mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages
    Oh, Min-Hee
    Collins, Samuel L.
    Sun, Im-Hong
    Tam, Ada J.
    Patel, Chirag H.
    Arwood, Matthew L.
    Chan-Li, Yee
    Powell, Jonathan D.
    Horton, Maureen R.
    CELL REPORTS, 2017, 20 (10): : 2439 - 2454
  • [50] HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages
    Woods, Parker S.
    Cetin-Atalay, Rengul
    Meliton, Angelo Y.
    Sun, Kaitlyn A.
    Shamaa, Obada R.
    Shin, Kun Woo D.
    Tian, Yufeng
    Haugen, Benjamin
    Hamanaka, Robert B.
    Mutlu, Gokhan M.
    SCIENTIFIC REPORTS, 2025, 15 (01):