Can gray values derived from CT and cone beam CT estimate new bone formation? An in vivo study

被引：10
作者：
Bastami F. [1 ]
Shahab S. [2 ]
Parsa A. [3 ]
Abbas F.M. [4 ]
Noori Kooshki M.H. [2 ]
Namdari M. [5 ]
Lisar H.A. [6 ]
Rafiei T. [6 ]
Fahimipour F. [7 ]
Salehi M. [8 ]
Jafari M. [9 ]
机构：
[1] Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran
[2] Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahed University, Tehran
[3] Department of Oral Radiology, Department of General and Specialized Dentistry, Academic Center for Dentistry Amsterdam (ACTA), Amsterdam
[4] Department of Oral Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran
[5] Department of Biostatistics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran
[6] Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahed University, Tehran
[7] Department of Developmental Sciences, School of Dentistry, Marquette University, Milwaukee, WI
[8] Department of Tissue Engineering and Cell Therapy, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran
[9] Department of Oral Radiology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran
来源：
Oral and Maxillofacial Surgery | 2018年 / 22卷 / 1期
关键词：
Bone regeneration; Cone beam computed tomography; CT number; Hounsfield unit; New bone formation;
D O I：
10.1007/s10006-017-0657-7
中图分类号：
学科分类号：
摘要：
Objectives: The main aim of this study was to investigate whether Hounsfield unit derived from computed tomography (HU/CT) and gray value derived from cone beam computed tomography (GV/CBCT) can predict the amount of new bone formation (NBF) in the defects after bone reconstruction surgeries. Materials and methods: Thirty calvaria defects created in 5 rabbits and grafted with both radiolucent (RL, n = 15) and radiopaque (RO, n = 15) bone substitute materials were evaluated, 8 weeks postoperatively. The defects were scanned by multislice computed tomography (Somatom®, Siemens Healthineers, Erlangen, Germany) and CBCT (NewTom VG®, Qualitative Radiology, Verona, Italy). MSCT and CBCT scans were matched to select the exact region of interest (ROI, diameter = 5 mm and height = 1 mm). HU/CT and GV/CBCT of each ROI were obtained. Mean amount of NBF in whole of the defects was measured using serial histomorphometric assessment. We investigated the correlation between HU/CT and GV/CBCT, HU/CT and NBF, and GV/CBCT and NBF generally, and separately among the RL or RO grafted defects, by linear generalized estimating equation modeling. Receiver operation characteristic analysis was performed to check the accuracy of HU/CT and GV/CBCT in diagnosing more than 10% NBF in the samples. Results: There were linear correlations between HU/CT and GV/CBCT, HU/CT and NBF, and GV/CBCT and NBF. Conclusion: According to the results, both HU/CT and GV/CBCT can be considered as fairly good predictors for assessment of the amount of NBF following bone reconstruction surgeries. © 2017, Springer-Verlag GmbH Germany.
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页码：13 / 20
页数：7
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