Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes

被引：0
|
作者：
Louise Cottle
Wan Jun Gan
Ian Gilroy
Jaswinder S. Samra
Anthony J. Gill
Thomas Loudovaris
Helen E. Thomas
Wayne J. Hawthorne
Melkam A. Kebede
Peter Thorn
机构：
[1] University of Sydney,Charles Perkins Centre, Discipline of Physiology, School of Medical Sciences
[2] Temasek Life-Science Laboratory,Upper Gastrointestinal Surgical Unit
[3] The University of Sydney Northern Clinical School,Department of Anatomical Pathology
[4] Royal North Shore Hospital,Cancer Diagnosis and Pathology Research Group
[5] Royal North Shore Hospital,The University of Melbourne, Department of Medicine
[6] Kolling Institute of Medical Research,Centre for Transplant and Renal Research
[7] St Vincent’s Institute,Westmead Clinical School, Faculty of Health and Medicine
[8] St Vincent’s Hospital,undefined
[9] Westmead Hospital,undefined
[10] University of Sydney,undefined
来源：
Diabetologia | 2021年 / 64卷
关键词：
Beta cell; Diabetes; Human; Insulin; Islet; Polarity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：618 / 629
页数：11
相关论文
共 50 条
  • [41] IL-17 is expressed on beta and alpha cells of donors with type 1 and type 2 diabetes
    Rajendran, Sakthi
    Quesada-Masachs, Estefania
    Zilberman, Samuel
    Graef, Madeleine
    Kiosses, William B.
    Chu, Tiffany
    Benkahla, Mehdi A.
    Lee, Jae-Hyun Mason
    von Herrath, Matthias
    JOURNAL OF AUTOIMMUNITY, 2021, 123
  • [42] Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?
    Kahraman, Sevim
    Okawa, Erin R.
    Kulkarni, Rohit N.
    CURRENT DIABETES REPORTS, 2016, 16 (08)
  • [43] Pseudotime Ordering Single-Cell Transcriptomic of β Cells Pancreatic Islets in Health and Type 2 Diabetes
    Bao, Kaixuan
    Cui, Zhicheng
    Wang, Hui
    Xiao, Hui
    Li, Ting
    Kong, Xingxing
    Liu, Tiemin
    PHENOMICS, 2021, 1 (05): : 199 - 210
  • [44] Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes
    Khamis, Amna
    Canouil, Mickael
    Siddiq, Afshan
    Crouch, Hutokshi
    Falchi, Mario
    von Bulow, Manon
    Ehehalt, Florian
    Marselli, Lorella
    Distler, Marius
    Richter, Daniela
    Weitz, Juergen
    Bokvist, Krister
    Xenarios, Ioannis
    Thorens, Bernard
    Schulte, Anke M.
    Ibberson, Mark
    Bonnefond, Amelie
    Marchetti, Piero
    Solimena, Michele
    Froguel, Philippe
    MOLECULAR METABOLISM, 2019, 24 : 98 - 107
  • [45] TCR Bias of In Vivo Expanded T Cells in Pancreatic Islets and Spleen at the Onset in Human Type 1 Diabetes
    Codina-Busqueta, Eva
    Scholz, Erika
    Munoz-Torres, Pau M.
    Roura-Mir, Carme
    Costa, Manuela
    Xufre, Cristina
    Planas, Raquel
    Vives-Pi, Marta
    Jaraquemada, Dolores
    Marti, Merce
    JOURNAL OF IMMUNOLOGY, 2011, 186 (06) : 3787 - 3797
  • [46] Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?
    Sevim Kahraman
    Erin R. Okawa
    Rohit N. Kulkarni
    Current Diabetes Reports, 2016, 16
  • [47] Interleukin-4 reduces insulin secretion in human islets from healthy but not type-2 diabetic donors
    Westholm, Efraim
    Edlund, Anna
    Karagiannopoulos, Alexandros
    Wendt, Anna
    Eliasson, Lena
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 649 : 87 - 92
  • [48] Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets
    Bergholdt, R.
    Karlsen, A. E.
    Hagedorn, P. H.
    Aalund, M.
    Nielsen, J. H.
    Kruhoffer, M.
    Orntoft, T.
    Wang, H.
    Wollheim, C. B.
    Nerup, J.
    Pociot, F.
    GENES AND IMMUNITY, 2007, 8 (03) : 232 - 238
  • [49] Differentiation and Transplantation of Functional Pancreatic Beta Cells Generated from Induced Pluripotent Stem Cells Derived from a Type 1 Diabetes Mouse Model
    Jeon, Kilsoo
    Lim, Hyejin
    Kim, Jung-Hyun
    Nguyen Van Thuan
    Park, Seung Hwa
    Lim, Yu-Mi
    Choi, Hye-Yeon
    Lee, Eung-Ryoung
    Kim, Jin-Hoi
    Lee, Myung-Shik
    Cho, Ssang-Goo
    STEM CELLS AND DEVELOPMENT, 2012, 21 (14) : 2642 - 2655
  • [50] Functional pancreatic beta-cell mass: Involvement in type 2 diabetes and therapeutic intervention
    Karaca, M.
    Magnan, C.
    Kargar, C.
    DIABETES & METABOLISM, 2009, 35 (02) : 77 - 84
12345