The roles of microRNAs in mouse development

被引:0
|
作者
Brian DeVeale
Jennifer Swindlehurst-Chan
Robert Blelloch
机构
[1] University of California,Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
[2] San Francisco,Center for Reproductive Sciences
[3] University of California,Department of Urology
[4] San Francisco,undefined
[5] University of California,undefined
[6] San Francisco,undefined
来源
Nature Reviews Genetics | 2021年 / 22卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns during embryonic and postnatal mouse development. The loss of all miRNAs through the deletion of critical miRNA biogenesis factors results in early lethality. The function of each miRNA stems from their cumulative negative regulation of multiple mRNA targets expressed in a particular cell type. During development, miRNAs often coordinate the timing and direction of cell fate transitions. In adults, miRNAs frequently contribute to organismal fitness through homeostatic roles in physiology. Here, we review how the recent dissection of miRNA-knockout phenotypes in mice as well as advances related to their targets, dosage, and interactions have collectively informed our understanding of the roles of miRNAs in mammalian development and adaptive responses.
引用
收藏
页码:307 / 323
页数:16
相关论文
共 50 条
  • [1] The roles of microRNAs in mouse development
    DeVeale, Brian
    Swindlehurst-Chan, Jennifer
    Blelloch, Robert
    NATURE REVIEWS GENETICS, 2021, 22 (05) : 307 - 323
  • [2] microRNAs and Their Roles in Plant Development
    Dong, Qingkun
    Hu, Binbin
    Zhang, Cui
    FRONTIERS IN PLANT SCIENCE, 2022, 13
  • [3] Evidence for Functional Roles of MicroRNAs in Lineage Specification During Mouse and Human Preimplantation Development
    Biondic, Savana
    Petropoulos, Sophie
    YALE JOURNAL OF BIOLOGY AND MEDICINE, 2023, 96 (04): : 481 - 494
  • [4] The Biological Roles of microRNAs in Drosophila Development
    Jang, Daegyu
    Kim, Chae Jeong
    Shin, Bo Hyun
    Lim, Do-Hwan
    INSECTS, 2024, 15 (07)
  • [5] MicroRNAs: roles in cardiovascular development and disease
    Kalayinia, Samira
    Arjmand, Fateme
    Maleki, Majid
    Malakootian, Mahshid
    Singh, Chandra Pal
    CARDIOVASCULAR PATHOLOGY, 2021, 50
  • [6] MicroRNAs in mouse development and disease
    Lewis, Morag A.
    Steel, Karen P.
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2010, 21 (07) : 774 - 780
  • [7] Big roles of microRNAs in tumorigenesis and tumor development
    Tie, Jun
    Fan, Daiming
    HISTOLOGY AND HISTOPATHOLOGY, 2011, 26 (10) : 1353 - 1361
  • [8] Roles of microRNAs beyond development - Metabolism and neural plasticity
    Aumiller, Verena
    Foerstemann, Klaus
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2008, 1779 (11): : 692 - 696
  • [9] Widespread roles of microRNAs during zebrafish development and beyond
    Mishima, Yuichiro
    DEVELOPMENT GROWTH & DIFFERENTIATION, 2012, 54 (01) : 55 - 65
  • [10] Maternal microRNAs are essential for mouse zygotic development
    Tang, Fuchou
    Kaneda, Masahiro
    O'Carroll, Donal
    Hajkova, Petra
    Barton, Sheila C.
    Sun, Y. Andrew
    Lee, Caroline
    Tarakhovsky, Alexander
    Lao, Kaiqin
    Surani, M. Azim
    GENES & DEVELOPMENT, 2007, 21 (06) : 644 - 648