Fundus autofluorescence in patients with pseudoxanthoma elasticum

被引：18
作者：
Shiraki K. [1 ]
Kohno T. [1 ]
Moriwaki M. [2 ]
Yanagihara N. [1 ]
机构：
[1] Department of Ophthalmology, Osaka City University, Medical School, Abeno-ku, Osaka 545-8585
[2] Department of Ophthalmology, Osaka City Juso Municipal Hospital, Osaka
来源：
International Ophthalmology | 2001年 / 24卷 / 5期
关键词：
Angioid streaks; Fundus autofluorescence; Heidelberg retina angiogram;
D O I：
10.1023/A:1025433431654
中图分类号：
学科分类号：
摘要：
Purpose: To characterize changes in fundus autofluorescence in patients with pseudoxanthoma elasticum (PXE). Fundus autofluorescence intrinsically derives from lipofuscin, and the degree of autofluorescence is thought to indicate the degree of retinal pigment epithelium (RPE) metabolic activity. Methods: Twelve eyes of 6 patients (2 men, 4 women) with PXE were studied with a confocal scanning laser ophthalmoscope. Patient age ranged from 42 to 62 years. The autofluorescence of abnormal retinal areas was compared digitally with that of neighboring, presumed healthy control areas. When the average gray level of a fundus region was 2 SDs above or below the average gray level of a control area, autofluorescence of the fundus region was considered abnormal. Results: In all 12 eyes, some segments of the angioid streaks showed decreased fundus autofluorescence, and other segments of the streaks showed normal autofluorescence. Areas of peripapillary chorioretinal atrophy seen in 2 eyes and of disciform scarring seen in 3 eyes showed decreased autofluorescence. Solitary or multiple drusen-like spots showed increased autofluorescence in all 12 eyes. Conclusion: Atrophic and degenerative RPE regions showed decreased fundus autofluorescence in areas of chorioretinal atrophy and in some segments of the angioid streaks. Some drusen-like spots showed increased autofluorescence. The characteristic changes in autofluorescence that we observed in PXE patients suggest that the content of the drusen-like substance differs from that of senile drusen and that the drusen-like lesions are similar to the sub-RPE deposits seen hi macular dystrophy.
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页码：243 / 248
页数：5
相关论文
共 26 条
  • [1] Von Ruckmann A., Fitzke F.W., Bird A.C., Autofluorescence imaging of the human fundus, The Retinal Pigment Epithelium. Function and Disease, pp. 224-234, (1998)
  • [2] Von Ruckmann A., Fitzke F.W., Bird A.C., Distribution of fundus autofluorescence with a scanning laser ophthalmoscope, Br J Ophthalmol, 79, pp. 407-412, (1995)
  • [3] Solbach U., Keilhauer C., Knabben H., Wolf S., Imaging of retinal autofluorescence in patients with age-related macular degeneration, Retina, 17, pp. 385-389, (1997)
  • [4] Von Ruckmann A., Fitzke F.W., Bird A.C., Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope, Invest Ophthalmol Vis Sci, 38, pp. 478-486, (1997)
  • [5] Spital G., Radermacher M., Muller C., Brumm G., Lommatzsch A., Pauleikhoff D., Autofluorescence characteristics of lipofuscin components in different forms of late senile macular degeneration, Klin Monatsbl Augenheilkd, 213, pp. 23-31, (1998)
  • [6] Von Ruckmann A., Fitzke F.W., Gregor Z.J., Fundus autofluorescence in patients with macular holes imaged with a laser scanning ophthalmoscope, Br J Ophthalmol, 82, pp. 346-351, (1998)
  • [7] Von Ruckmann A., Schmidt K.-G., Fitzke F.W., Bird A.C., Jacobi K.W., Autofluorescence of the retinal pigment epithelium in patients with central serous chorioretinopathy, Ophthalmologe, 96, pp. 6-10, (1999)
  • [8] Bellmann C., Holz F.G., Breitbart A., Volcker H.E., Bilateral acute syphilitic posterior placoid chorioretinopathy - Angiographic and autofluorescence characteristics, Ophthalmologe, 96, pp. 522-528, (1999)
  • [9] Von Ruckmann A., Fitzke F.W., Bird A.C., In vivo fundus autofluorescence in macular dystrophies, Arch Ophthalmol, 115, pp. 609-615, (1997)
  • [10] Downes S.M., Fitzke F.W., Holder G.E., Payne A.M., Bessant D.A.R., Bhattacharya S.S., Et al., Clinical features of codon 172 RDS macular dystrophy: Similar phenotype in 12 families, Arch Ophthalmol, 117, pp. 1373-1383, (1999)
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