Pathophysiological and diagnostic implications of cortical dysfunction in ALS

被引：0

作者：

Nimeshan Geevasinga

Parvathi Menon

P. Hande Özdinler

Matthew C. Kiernan

Steve Vucic

机构：

[1] Western Clinical School,Davee Department of Neurology and Clinical Neurological Sciences

[2] University of Sydney,undefined

[3] Westmead Hospital,undefined

[4] Northwestern University,undefined

[5] Feinberg School of Medicine,undefined

[6] Brain and Mind Research Institute,undefined

[7] University of Sydney,undefined

来源：

Nature Reviews Neurology | 2016年 / 12卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Cortical hyperexcitability is an early pathophysiological feature of amyotrophic lateral sclerosis (ALS)Cortical hyperexcitability potentially mediates motor neuron degeneration in ALS via a dying-forward, trans-synaptic, glutaminergic mechanismThe identification of the C9orf72 hexanucleotide repeat expansion as a major cause of familial and apparently sporadic ALS, as well as frontotemporal dementia, underscored the importance of cortical dysfunctionCortical hyperexcitability is an important diagnostic biomarker of ALS, and could enable more-definitive diagnosis at an earlier stage of the disease process

引用

页码：651 / 661

页数：10

共 50 条

[21] Unraveling the Metabolic Etiologies of Pancreatic Dysfunction: Pathophysiological Mechanisms and Clinical Implications
Rohban, Andrea
JOURNAL OF THE PANCREAS, 2024, 25 (01): : 17 - 18
[22] SLEEP STUDIES IN AFFECTIVE-ILLNESS - DIAGNOSTIC, THERAPEUTIC, AND PATHOPHYSIOLOGICAL IMPLICATIONS
GILLIN, JC
PSYCHIATRIC ANNALS, 1983, 13 (05) : 367 - &
[23] Childhood obesity–related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements
Luc Bruyndonckx
Vicky Y Hoymans
Katrien Lemmens
José Ramet
Christiaan J Vrints
Pediatric Research, 2016, 79 : 831 - 837
[24] Mosaicism in malformations of cortical development: Implications for the diagnostic workflow
Fineschi, F.
Straka, B.
Mandorlini, C.
Vlckova, M.
Cetica, V.
Uhrova-Meszarosova, A.
Bianchini, C.
Kudr, M.
Cellini, E.
Krsek, P.
Timis, Ai
Bindi, C.
Rutigliano, D.
De Vita, D.
Pucatti, D.
Virdo, S.
Delledonne, M.
Parrini, E.
Guerrini, R.
Mei, D.
EPILEPSIA, 2024, 65 : 48 - 48
[25] Early potentials of direct cortical responses: Experimental study in dogs and pathophysiological and clinical implications
Nishikata, M
Endo, S
Yamatani, K
Hayashi, N
Masuda, R
Takaku, A
NEUROSURGERY, 1998, 43 (02) : 325 - 329
[26] Childhood obesity-related endothelial dysfunction: an update on pathophysiological mechanisms and diagnostic advancements
Bruyndonckx, Luc
Hoymans, Vicky Y.
Lemmens, Katrien
Ramet, Jose
Vrints, Christiaan J.
PEDIATRIC RESEARCH, 2016, 79 (06) : 831 - 837
[27] DIPYRIDAMOLE TEST IN ANGINA-PECTORIS - DIAGNOSTIC-VALUE AND PATHOPHYSIOLOGICAL IMPLICATIONS
TAVAZZI, L
PREVITALI, M
SALERNO, JA
CHIMIENTI, M
RAY, M
MEDICI, A
SPECCHIA, G
BOBBA, P
CARDIOLOGY, 1982, 69 (01) : 34 - 41
[28] Pathophysiological significance of fasciculations in the early diagnosis of ALS
de Carvalho, M
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS, 2000, 1 : S43 - S46
[29] Adipocyte accumulation in corpus cavernosum: First clinical evidence and pathophysiological implications in erectile dysfunction
Vinay, J.
Sarquetta, J.
Sanchez, J.
Atgaba, F.
Gattegos, I.
Ruiz-Castane, E.
Palma, C.
ACTAS UROLOGICAS ESPANOLAS, 2017, 41 (02): : 97 - 102
[30] The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications
Maiuolo, Jessica
Gliozzi, Micaela
Musolino, Vincenzo
Carresi, Cristina
Nucera, Saverio
Macri, Roberta
Scicchitano, Miriam
Bosco, Francesca
Scarano, Federica
Ruga, Stefano
Zito, Maria Caterina
Oppedisano, Francesca
Mollace, Rocco
Paone, Sara
Palma, Ernesto
Muscoli, Carolina
Mollace, Vincenzo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (12)

← 1 2 3 4 5 →