FK506 and the role of immunophilins in nerve regeneration

被引：0
作者：
Bruce G. Gold
机构：
[1] Oregon Health Sciences University,Center for Research on Occupational and Environmental Toxicology
[2] Oregon Health Sciences University,Department of Cell and Developmental Biology
来源：
Molecular Neurobiology | 1997年 / 15卷
关键词：
Calcineurin; cyclosporin A; FK506; FKBP-12; glucocorticoid receptor; immunophilin; immunosuppressant; nerve regeneration;
D O I：
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中图分类号：
学科分类号：
摘要：
FK506 is a new FDA-approved immunosuppressant used for prevention of allograft rejection in, for example, liver and kidney transplantations. FK506 is inactive by itself and requires binding to an FK506 binding protein-12 (FKBP-12), or immunophilin, for activation. In this regard, FK506 is analogous to cyclosporin A, which must bind to its immunophilin (cyclophilin A) to display activity. This FK506-FKBP complex inhibits the activity of the serine/threonine protein phosphatase 2B (calcineurin), the basis for the immunosuppressant action of FK506. The discovery that immunophilins are also present in the nervous system introduces a new level of complexity in the regulation of neuronal function. Two important calcineurin targets in brain are the growth-associated protein GAP-43 and nitric oxide (NO) synthase (NOS).
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页码：285 / 306
页数：21
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