Nitrogen oxide generation during reduction of nitrofuran antibacterial drugs

被引：4

作者：

Grigor'ev N.B. ^{[1
]}

Chechekin G.V. ^{[1
]}

Arzamaztsev A.P. ^{[1
]}

Levina V.I. ^{[1
]}

Granik V.G. ^{[1
]}

机构：

[1] Russian Federation State Scientific Center NIOPIK

来源：

Chemistry of Heterocyclic Compounds | 1999年 / 35卷 / 7期

关键词：

Oxide; Nitrogen; Organic Chemistry; Biological Activity; Peroxynitrite;

D O I：

10.1007/BF02252100

中图分类号：

学科分类号：

摘要：

Proof of the nitrogen oxide generation during the chemical reduction of a series of nitrofuran derivatives is obtained by polarographic detection of the nitroprusside anion. A hypothesis is made about the mechanism of the peroxynitrite anion formation, which is responsible for the biological activity cf nitrofurans during the course of their reduction. ©1999 KluwerAcademic/Plenum Publishers.

引用

页码：788 / 791

页数：3

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