Acute myeloid leukemia with severe aplastic anemia following immunosuppressive therapy

被引：9
作者：
Sameer Bakhshi
Ajay Gupta
Lalit Kumar
机构：
[1] All India Institute of Medical Sciences,Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital
来源：
The Indian Journal of Pediatrics | 2006年 / 73卷 / 11期
关键词：
Aplastic anemia; Bone marrow transplantation; Immunosuppressive therapy; Leukemia;
D O I：
10.1007/BF02758313
中图分类号：
学科分类号：
摘要：
Severe aplastic anemia (AA) is a life-threatening condition wherein bone marrow transplantation (BMT) is the therapy of choice in a young patient who has a matched sibling donor. Here, we report an 11-year-old boy with severe AA who was referred for BMT late in its course when he had developed acute myeloid leukemia following two courses of immunosuppressive therapy with antithymocyte globulin and cyclosporin. He was then treated with induction therapy using cytosine arabinoside and daunomycin for acute myeloid leukemia, but he succumbed due to infection and refractory leukemia. We discuss the relevance of early referral for BMT in severe AA.
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页码：1033 / 1035
页数：2
相关论文
共 60 条
[1]  
Brodsky RA(2005)Aplastic Anemia Lancet 365 1647-1656
[2]  
Jones RJ(2005)Management of acquired aplastic anaemia Blood Rev 19 143-151
[3]  
Marsh JC(2000)Long-term outcome of acquired aplastic anaemia in children: comparison between immunosuppressive therapy and bone marrow transplantation Br J Haematol 111 321-328
[4]  
Kojima S(1998)Relapse and clonal disease in children with aplastic anemia (AA) after immunosuppressive therapy (IST): the SAA 94 experience. German/Austrian Pediatric Aplastic Anemia Working Group Klin Padiatr 210 173-179
[5]  
Horibe K(2000)Current status of allogeneic bone marrow transplantation in acquired aplastic anemia Semin Hematol 37 30-42
[6]  
Inaba J(2000)Treatment of acquired severe aplastic anemia: bone marrow transplantation compared with immunosuppressive therapy-The European Group for Blood and Marrow Transplantation experience Semin Hematol 37 69-80
[7]  
Yoshimi A(1997)Myelodysplastic syndrome and acute myelogenous leukemia as a late clonal complication in children with acquired aplastic anemia Blood 90 1009-1101
[8]  
Takahashi Y(2000)Alternative-donor hematopoietic stem-cell transplantation for severe aplastic anemia Semin Hematol 37 43-55
[9]  
Kudo K(2002)Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children Blood 100 786-790
[10]  
Kato K(1993)Acute monocytic leukemia following anti-lymphocyte immunoglobulin treatment in a patient with severe aplastic anemia Rinsho Ketsueki (Japanese) 34 673-675
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