Non-response to Cardiac Resynchronization Therapy

被引：19
作者：
Naqvi S.Y. [1 ]
Jawaid A. [1 ]
Goldenberg I. [1 ]
Kutyifa V. [1 ]
机构：
[1] Heart Research Follow-Up Program, Cardiology Division, University of Rochester Medical Center, 265 Crittenden Blvd., Box 653, Rochester, 14642, NY
来源：
Current Heart Failure Reports | 2018年 / 15卷 / 5期
关键词：
Cardiac function; Cardiac resynchronization therapy; CRT; CRT non-response; CRT response; Heart failure;
D O I：
10.1007/s11897-018-0407-7
中图分类号：
学科分类号：
摘要：
Purpose of Review: Cardiac resynchronization therapy (CRT) is an effective treatment option for therapy-refractory mild to severe heart failure (HF) patients with reduced ejection fraction and left ventricular (LV) conduction delay. Multiple clinical trials have shown that CRT improves cardiac function and overall quality of life, as well as reduces HF hospitalizations, health care costs, and mortality. Recent Findings: Despite its effectiveness, the “non-response” rate to CRT is around 30%, remaining a major challenge that faces electrophysiologists and researchers. It has been recently suggested that the etiology of CRT non-response is multifactorial, and it requires a multifaceted approach to address it. Summary: In this focused review, we will summarize the definitions of CRT non-response, identify key factors for CRT non-response, and offer a simplified framework to address CRT non-response with the main goal of improving CRT outcomes. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
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页码：315 / 321
页数：6
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