Bisphosphonate-induced zebra lines in fibrous dysplasia of bone: histo-radiographic correlation in a case of McCune–Albright syndrome

被引:1
作者
Alessandro Corsi
Ernesto Ippolito
Pamela G. Robey
Mara Riminucci
Alan Boyde
机构
[1] Sapienza University,Department of Molecular Medicine
[2] University of Rome Tor Vergata,Department of Orthopaedic Surgery
[3] Skeletal Biology Section,Dental Physical Sciences
[4] National Institute of Dental and Craniofacial Research,undefined
[5] National Institutes of Health,undefined
[6] Department of Health and Human Services,undefined
[7] Queen Mary University of London,undefined
来源
Skeletal Radiology | 2017年 / 46卷
关键词
Fibrous dysplasia; McCune–Albright syndrome; Bisphosphonates; Zebra lines; Contact microradiography; BSE-SEM image analysis;
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摘要
Bisphosphonates (BPs) are currently used in the treatment of diverse bone diseases including fibrous dysplasia of bone (FD). In pediatric patients, a radiographic consequence of cyclical administration of BPs is the development of apo-, epi-, and meta-physeal sclerotic bands, otherwise known as zebra lines, which result from the temporary inhibition of osteoclastic activity at the time of drug treatment. We report here on a child with McCune–Albright syndrome (FD in addition to hyperfunctioning endocrinopathies and skin hyperpigmentation) treated with cyclical intravenous infusions of pamidronate in which conventional radiography, contact microradiography, histology, and backscattered electron image analysis demonstrated that zebra lines formed only where bone was normal, were arrested at the boundary between FD-unaffected and FD-affected bone where bone is sclerotic, and were absent within the undermineralized FD bone. Moreover, in spite of the treatment, the FD lesions continued to expand. This case report is unique because no previously published studies correlated the radiographic and the histologic features of BP-induced zebra lines in the metaphysis of an FD-affected long bone of the limbs.
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页码:1435 / 1439
页数:4
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  • [1] Al Muderis M(2007)Zebra lines of pamidronate therapy in children J Bone Joint Surg Am 89 1511-1516
  • [2] Azzopardi T(1973)Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats Calcif Tissue Res 11 196-214
  • [3] Cundy P(1992)Epi- and metaphyseal changes in children caused by administration of bisphosphonates Radiology 184 249-254
  • [4] Schenk R(2004)Sclerotic metaphyseal lines in a child treated with pamidronate:histomorphometric analysis J Bone Min Res. 19 1191-1193
  • [5] Merz WA(2003)Radiographic features of bisphosphonate therapy in pediatric patients Pediatr Radiol 33 226-229
  • [6] Mühlbauer R(2011)Images in clinical medicine. Radiographic zebra lines from cyclical pamidronate therapy N Engl J Med 365 e5-714
  • [7] Russell RG(2007)Bisphosphonates Skelet Radiol 36 711-1246
  • [8] Fleisch H(2003)Osteomalacic and hyperparathyroid changes in fibrous dysplasia of bone: core biopsy studies and clinical correlations J Bone Min Res 18 1235-442
  • [9] Van Persijn van Meerten EL(2003)Osteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression Bone 33 434-954
  • [10] Kroon HM(1994)Long-term effects of intravenous pamidronate in fibrous dysplasia of bone Lancet 343 953-1752