Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

被引：0
|
作者：
Wenhui Qiao
Yixing Chen
Jun Zhong
Benjamin J. Madden
Cristine M. Charlesworth
Yuka A. Martens
Chia-Chen Liu
Joshua Knight
Tadafumi C. Ikezu
Aishe Kurti
Yiyang Zhu
Axel Meneses
Cassandra L. Rosenberg
Lindsey A. Kuchenbecker
Lucy K. Vanmaele
Fuyao Li
Kai Chen
Francis Shue
Maxwell V. Dacquel
John Fryer
Akhilesh Pandey
Na Zhao
Guojun Bu
机构：
[1] Mayo Clinic,Department of Neuroscience
[2] Mayo Clinic,Department of Laboratory Medicine and Pathology
[3] Mayo Clinic,Medical Genome Facility, Proteomics Core
[4] Mayo Clinic,Department of Neuroscience
[5] Mayo Clinic,Center for Individualized Medicine
[6] Manipal Academy of Higher Education (MAHE),undefined
[7] SciNeuro Pharmaceuticals,undefined
来源：
Molecular Neurodegeneration | / 18卷
关键词：
H157Y mutation; Soluble TREM2; Microglia; Synaptic plasticity; Amyloid pathology; Aβ clearance;
D O I：
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