A phase 1 pharmacokinetic study of oral NEPA, the fixed combination of netupitant and palonosetron, in Chinese healthy volunteers

被引：0
|
作者：
Rui Chen
Hongyun Wang
Wen Zhong
Salvatore Chessari
Corinna Lanzarotti
Alberto Bernareggi
Pei Hu
机构：
[1] Peking Union Medical College Hospital,Clinical Pharmacology Research Center
[2] Helsinn Healthcare SA,Scientific Operations Division
来源：
Cancer Chemotherapy and Pharmacology | 2021年 / 87卷
关键词：
Antiemetic; NEPA; Netupitant; Palonosetron; Pharmacokinetics; China;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：387 / 396
页数：9
相关论文
共 50 条
  • [21] Profile of netupitant/palonosetron (NEPA) fixed dose combination and its potential in the treatment of chemotherapy-induced nausea and vomiting (CINV)
    Navari, Rudolph M.
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2014, 9 : 155 - 161
  • [22] Effect of netupitant, a highly selective NK1 receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives
    Selma Calcagnile
    Corinna Lanzarotti
    Giorgia Rossi
    Anders Henriksson
    Klaus Peter Kammerer
    Wolfgang Timmer
    Supportive Care in Cancer, 2013, 21 : 2879 - 2887
  • [23] Timing flexibility of oral NEPA, netupitant-palonosetron combination, administration for the prevention of chemotherapy-induced nausea and vomiting (CINV)
    Baron-Hay, Sally
    Aapro, Matti
    Bernareggi, Alberto
    Schwartzberg, Lee
    SUPPORTIVE CARE IN CANCER, 2019, 27 (04) : 1309 - 1317
  • [24] Timing flexibility of oral NEPA, netupitant-palonosetron combination, administration for the prevention of chemotherapy-induced nausea and vomiting (CINV)
    Sally Baron-Hay
    Matti Aapro
    Alberto Bernareggi
    Lee Schwartzberg
    Supportive Care in Cancer, 2019, 27 : 1309 - 1317
  • [25] A phase III study evaluating the safety and efficacy of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting over repeated cycles of chemotherapy
    Gralla, R. J.
    Bosnjak, S. M.
    Hontsa, A.
    Balser, C.
    Rizzi, G.
    Rossi, G.
    Borroni, M. E.
    Jordan, K.
    ANNALS OF ONCOLOGY, 2014, 25 (07) : 1333 - 1339
  • [26] Pharmacokinetics and safety evaluation of oral Palonosetron in Chinese healthy volunteers: A phase 1, open-label, randomized, cross-over study
    Chen, Rui
    Wang, Hongyun
    Zhong, Wen
    Chessari, Salvatore
    Lanzarotti, Corinna
    Bernareggi, Alberto
    Hu, Pei
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 160
  • [27] Pharmacokinetic study of levofloxacin in Chinese healthy volunteers
    Zhang, Li
    Li, Jia-Tai
    Lü, Yuan
    Li, Man-Ning
    Zhang, Yong-Long
    Liu, Yan
    Li, Tian-Yun
    Zhang, Jian-Wei
    Chinese Pharmaceutical Journal, 2001, 36 (12) : 834 - 837
  • [28] A randomized phase III study evaluating the efficacy and safety of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy
    Aapro, M.
    Rugo, H.
    Rossi, G.
    Rizzi, G.
    Borroni, M. E.
    Bondarenko, I.
    Sarosiek, T.
    Oprean, C.
    Cardona-Huerta, S.
    Lorusso, V.
    Karthaus, M.
    Schwartzberg, L.
    Grunberg, S.
    ANNALS OF ONCOLOGY, 2014, 25 (07) : 1328 - 1333
  • [29] Evaluation of the Effect of Food and Age on the Pharmacokinetics of Oral Netupitant and Palonosetron in Healthy Subjects: A Randomized, Open-Label, Crossover Phase 1 Study
    Calcagnile, Selma
    Lanzarotti, Corinna
    Gutacker, Michaela
    Jakob-Rodamer, Verena
    Kammerer, Klaus Peter
    Timmer, Wolfgang
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2015, 4 (05): : 377 - 386
  • [30] Phase 3 study of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting during repeated moderately emetogenic chemotherapy (MEC) cycles.
    Aapro, Matti S.
    Karthaus, Meinolf
    Schwartzberg, Lee Steven
    Rossi, Giorgia
    Rizzi, Giada
    Borroni, Maria Elisa
    Palmas, Marco
    Rugo, Hope S.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
12345