Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

被引：0
|
作者：
Mark P. Foster
Deborah S. Wuttke
Ishwar Radhakrishnan
David A. Case
Joel M. Gottesfeld
Peter E. Wright
机构：
[1] The Scripps Research Institute,Department of Molecular Biology and the Skaggs Institute for Chemical Biology
[2] The Scripps Research Institute,Department of Molecular Biology
[3] University of Colorado,Department of Chemistry and Biochemistry
来源：
Nature Structural Biology | 1997年 / 4卷
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摘要：
The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.
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页码：605 / 608
页数：3
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