Haemolytic disease of newborn

被引：20
作者：
Narang A. [1 ,2 ]
Jain N. [1 ]
机构：
[1] Neonatal Division, Department of Pediatrics, Postgrad. Inst. Med. Educ. and Res., Chandigarh
[2] Neonatal Division, Dept. of Pediatrics, PGIMER, Chandigarh
来源：
The Indian Journal of Pediatrics | 2001年 / 68卷 / 2期
关键词：
Antenatal approach; Management Prophylaxis; Neonate; Rh hemolytic disease;
D O I：
10.1007/BF02722039
中图分类号：
学科分类号：
摘要：
Hemolytic disease of the newborn (HDN) occurs due to maternal IgG antibodies crossing the placenta thereby producing hemolysis mainly due to Rh, ABO and Kell groups. A systematic approach to the Rh HDN involves an obstetric history of previous isoimmunised baby, timing and regular monitoring of maternal Rh antibodies and pigment assay of amniotic fluid. Timely decision regarding in utero transfusion and early termination of pregnancy based on the maternal monitoring has radically improved the outcome of these babaies. Antenatal prophylaxis with anti D has resulted in great reduction in the magnitude of Rh problem. The fetal blood sampling and in-utero intravenous transfusions has made it possible for almost 100% survival of isoimmunised pregnancies without hydrops. Alternative methods - IVIG and plasma exchange are still of limited application. ABO HDN though common is not a serious form of disease and dose not warrants invasive antenatal monitoring. Anti-Kell is found in patients having received multiple transfusions and the rapid progress of hemolysis in them may not allow such systematic follow up as in Rh HDN.
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页码：167 / 172
页数：5
相关论文
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