Distribution of abo genotypes and allele frequencies in a korean population

被引：0
|
作者：
Sung Ha Kang
Yasuo Fukumori
Shiro Ohnoki
Hirotoshi Shibata
Kyou Sup Han
Hiroaki Nishimukai
Yasuto Okubo
机构：
[1] Osaka Red Cross Blood Center,Department of Clinical Pathology
[2] Hallym University Hospital,Department of Clinical Pathology
[3] Seoul National University,Department of Legal Medicine, School of Medicine
[4] College of Medicine,undefined
[5] Ehime University,undefined
来源：
Japanese Journal of Human Genetics | 1997年 / 42卷
关键词：
ABO blood group; genotyping; PCR-RFLP; Korean population;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The genotypes of the ABO blood group system were investigated in Korean living in Kangwon-Do area by PCR-RFLP analysis of the seven polymorphic nucleotide positions 261, 467, 526, 646, 703, 796 and 803 of the cDNA from A1 transferase. In 253 unrelated Korean individuals, 15 genotypes were found and the allele frequencies of A(Pro), A(Leu), B, O(T) and O(A) were 0.022, 0.209, 0.209, 0.360 and 0.200, respectively, with no deviation from Hardy-Weinberg expectations (x2=2.145, d.f.=6, 0.90<p<0.95). As for the distribution of allele frequencies, a significant difference was noticed between the Korean and a Japanese (x2=30.87, d.f.=4, p<0.001) and a German (x2=127.76, d.f.=4, p<0.001) populations.
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页码：331 / 335
页数：4
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