Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

被引:0
作者
Michael X. Hernandez
Shan Jiang
Tracy A. Cole
Shu-Hui Chu
Maria I. Fonseca
Melody J. Fang
Lindsay A. Hohsfield
Maria D. Torres
Kim N. Green
Rick A. Wetsel
Ali Mortazavi
Andrea J. Tenner
机构
[1] University of California,Department of Pathology and Laboratory Medicine, School of Medicine
[2] University of California,Department of Developmental and Cell Biology
[3] University of California,Department of Neurobiology and Behavior
[4] University of California,Department of Molecular Biology and Biochemistry
[5] University of Texas-Houston,Research Center for Immunology and Autoimmune Diseases, Institute of Molecular Medicine for the Prevention of Human Diseases
[6] Present Address: Ionis Pharmaceuticals Inc.,undefined
来源
Molecular Neurodegeneration | / 12卷
关键词
C5a; C5a receptor; Alzheimer’s disease; Complement; Microglia; Mouse models; Behavior; Gene expression; Inflammation; Phagosome;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 526 条
[41]  
Sanderson SD(2014)Next maSigPro: updating maSigPro bioconductor package for RNA-seq time series Bioinformatics 30 723-2562
[42]  
LaFerla FM(2015)Meta- and orthogonal integration of influenza "OMICs" data defines a role for UBR4 in virus budding Cell Host Microbe 18 137-17101
[43]  
Taylor SM(2011)Paintomics: a web based tool for the joint visualization of transcriptomics and metabolomics data Bioinformatics 27 618-438
[44]  
Woodruff TM(2008)The consolidation of object and context recognition memory involve different regions of the temporal lobe LearnMem 15 49-539
[45]  
Tenner AJ(2002)Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts LearnMem 9 29-182
[46]  
El Khoury J(2012)The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood J Immunol 188 2549-7262
[47]  
Luster AD(2010)CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models AmJ Pathol 177 17091-533
[48]  
Huang KL(2010)CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis JNeurosci 30 432-3019
[49]  
Marcora E(2007)Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease Nat Med 13 51-82
[50]  
Pimenova AA(2008)Inflammaging as a prodrome to Alzheimer's disease J Neuroinflammation 5 535-98